ArticlePediatrics2013
Mortality risks in new-onset childhood epilepsy.
Article in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Premature Mortality, Risk Factors, and Causes of Death Following Childhood-Onset Neurological Impairments: A Systematic Review.Frontiers in neurology · 2021Pooled it
- Autonomic Characteristics of Sudden Unexpected Death in Epilepsy in Children-A Systematic Review of Studies and Their Relevance to the Management of Epilepsy in Rett Syndrome.Frontiers in neurology · 2020Pooled it
- Pooled it
- Age-specific MRI patterns in pediatric epilepsy: insights from a sudanese cohort and implications for low-resources settings.BMC medical imaging · 2026Article
- Death Causes Among Iranian Children With Leukodystrophies.Journal of child neurology · 2025Article
- Brain gray matter changes in children at risk for sudden unexpected death in epilepsy.Pediatric research · 2024Article
- Norwegian population-based study of effectiveness of vagus nerve stimulation in patients with developmental and epileptic encephalopathies.Epilepsia open · 2024Article
- Impact of prenatal, neonatal, and postnatal factors on epilepsy risk in children and adolescents: a systematic review and meta-analysis.Acta epileptologica · 2024Article
- Mortality, and life expectancy in Epilepsy and Status epilepticus-current trends and future aspects.Frontiers in epidemiology · 2023Review
- A review of the causes and risk factors for sudden unexpected death in the young.Forensic science, medicine, and pathology · 2022Review
- Article
- EEG biomarkers for the diagnosis and treatment of infantile spasms.Frontiers in neurology · 2022Review
- Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability.Behavioural neurology · 2022Review
- Regulation of microRNA Expression in Sleep Disorders in Patients with Epilepsy.International journal of molecular sciences · 2021Review
- Epilepsy and COVID-19: Updated evidence and narrative review.Epilepsy & behavior : E&B · 2021Review
- Why child neurologists talk about SUDEP: Results from two cross-sectional surveys.Epilepsia open · 2021Article
- Indications for Inpatient Magnetoencephalography in Children - An Institution's Experience.Frontiers in human neuroscience · 2021Article
- Article
- Article
- Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.Laboratory investigation; a journal of technical methods and pathology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivesEstimate the causes and risk of death, specifically seizure related, in children followed from onset of epilepsy and to contrast the risk of seizure-related death with other common causes of death in the population.
methodsMortality experiences from 4 pediatric cohorts of newly diagnosed patients were combined. Causes of death were classified as seizure related (including sudden unexpected death [SUDEP]), natural causes, nonnatural causes, and unknown.
resultsOf 2239 subjects followed up for >30 000 person-years, 79 died. Ten subjects with lethal neurometabolic conditions were ultimately excluded. The overall death rate (per 100 000 person-years) was 228; 743 in complicated epilepsy (with associated neurodisability or underlying brain condition) and 36 in uncomplicated epilepsy. Thirteen deaths were seizure-related (10 SUDEP, 3 other), accounting for 19% of all deaths. Seizure-related death rates were 43 overall, 122 for complicated epilepsy, and 14 for uncomplicated epilepsy. Death rates from other natural causes were 159, 561, and 9, respectively. Of 48 deaths from other natural causes, 37 were due to pneumonia or other respiratory complications.
conclusionsMost excess death in young people with epilepsy is not seizure-related. Mortality is significantly higher compared with the general population in children with complicated epilepsy but not uncomplicated epilepsy. The SUDEP rate was similar to or higher than sudden infant death syndrome rates. In uncomplicated epilepsy, sudden and seizure-related death rates were similar to or higher than rates for other common causes of death in young people (eg, accidents, suicides, homicides). Relating the risk of death in epilepsy to familiar risks may facilitate discussions of seizure-related mortality with patients and families.
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