Trial reportPediatrics2013
The RIVUR trial: profile and baseline clinical associations of children with vesicoureteral reflux.
Trial report in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00405704 (Randomized Intervention for Children With Vesicoureteral Reflux), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Long-term antibiotics for preventing recurrent urinary tract infection in children.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions for primary vesicoureteric reflux.The Cochrane database of systematic reviews · 2019Pooled it
- Why Does Prevention of Recurrent Urinary Tract Infection not Result in Less Renal Scarring? A Deeper Dive into the RIVUR Trial.The Journal of urology · 2019Trial
- Targeted Workup after Initial Febrile Urinary Tract Infection: Using a Novel Machine Learning Model to Identify Children Most Likely to Benefit from Voiding Cystourethrogram.The Journal of urology · 2019Trial
- Variation in the level of detail in pediatric voiding cystourethrogram reports.Journal of pediatric urology · 2017Trial
- Reliability of grading of vesicoureteral reflux and other findings on voiding cystourethrography.Journal of pediatric urology · 2017Trial
- Renal Scarring in the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) Trial.Clinical journal of the American Society of Nephrology : CJASN · 2016Trial
- Diagnostic accuracy of urine heparin binding protein for pediatric acute pyelonephritis.European journal of pediatrics · 2015Trial
- Antimicrobial prophylaxis for children with vesicoureteral reflux.The New England journal of medicine · 2014Trial
- Urobiota analysis and genome-wide association study in pediatric recurrent urinary tract infections and vesicoureteral reflux.JCI insight · 2026Article
- Digital droplet PCR is an accurate and precise method to measure DNA copy number.Scientific reports · 2025Article
- Antimicrobial prophylaxis for vesicoureteral reflux: which subgroups of children benefit the most?Pediatric nephrology (Berlin, Germany) · 2024Article
- Long-term consequences of urinary tract infection in childhood: an electronic population-based cohort study in Welsh primary and secondary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024Article
- Risk factors for imaging abnormalities after the first febrile urinary tract infection in infants ≤3 months old: a retrospective cohort study.BMJ paediatrics open · 2023Article
- Innate Bacteriostatic Mechanisms Defend the Urinary Tract.Annual review of physiology · 2022Review
- Accuracy of subjective vesicoureteral reflux timing assessment: supporting new voiding cystourethrogram guidelines.Pediatric radiology · 2020Article
- [Long-term prognosis of vesicoureteral reflux: a follow-up observation of 138 children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Managing vesicoureteral reflux in children: making sense of all the data.F1000Research · 2019Review
- DNA copy number variations in children with vesicoureteral reflux and urinary tract infections.PloS one · 2019Article
- Interobserver variability for interpretation of DMSA scans in the RIVUR trial.Journal of pediatric urology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveVesicoureteral reflux (VUR) is diagnosed in ∼30% to 40% of children who have imaging studies after urinary tract infections (UTIs). Our goal is to characterize children enrolled in the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial and to compare our study cohort with those from previously published studies.
methodsRIVUR investigators from 19 pediatric sites in the United States recruited 607 children with grade I through IV VUR. Children were enrolled after a first or second UTI. This cross-sectional report of baseline data includes extensive clinical, parental report, and imaging study results.
resultsRIVUR recruited 607 children (558 girls, 49 boys) with grade I (11%), II (42%), III (38%), or IV (8%) reflux. The median age was 12 months, and most children (91%) were enrolled after their first UTI. The UTI leading to enrollment was both febrile and symptomatic for 323 children, febrile only in 197 children, and symptomatic only in 86. Renal involvement at baseline as documented by a (99m)Tc dimercaptosuccinic acid scan was uncommon with cortical defects identified in 89 (15%) children. Bladder and bowel dysfunction was identified in 71 (56%) of 126 toilet-trained subjects assessed.
conclusionsRIVUR is the largest prospective, randomized trial for children with primary VUR to date, comparing prophylaxis with placebo. The study sample comprises patients from 19 pediatric clinical sites in the United States, whose demographic and clinical characteristics may differ from those of children enrolled in previous trials from other countries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.