ReviewInternational journal of molecular sciences2013
Urinary bladder cancer susceptibility markers. What do we know about functional mechanisms?
Review in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Exploring the Relationship betweenGenes · 2023Article
- Genetic Polymorphisms Involved in Bladder Cancer: A Global Review.Oncology reviews · 2023Article
- Implications of risk conferred by 5p15.33 loci genetic variants; human telomerase reverse transcriptase rs2736098 and rs2736100 in predisposition of bladder cancer.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022Article
- Molecular Detection of Genetic Susceptibility to Bladder Cancer in Egyptian Patients.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Associations between inflammasome-related gene NLRP3 Polymorphisms (rs10754558 and rs35829419) and risk of bladder cancer in a Chinese population.Journal of clinical laboratory analysis · 2021Article
- Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran.BMC medical genetics · 2020Article
- The association between matrix metalloproteinase-7 genetic variant and bladder cancer risk in a Chinese Han population.Clinical and experimental medicine · 2019Article
- Identification of an enhancer region within the TP63/LEPREL1 locus containing genetic variants associated with bladder cancer risk.Cellular oncology (Dordrecht, Netherlands) · 2018Article
- PSCArs2294008 T polymorphism increases the risk of bladder cancer in Bai, Dai, and Han ethnicity in China and a potential mechanism.Genes & genomics · 2018Article
- Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer.Carcinogenesis · 2017Article
- Increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of bladder cancer.British journal of cancer · 2017Article
- Discovering urinary bladder cancer risk variants: Status quo after almost ten years of genome-wide association studies.EXCLI journal · 2017Article
- [A critical perspective on the global research activity in the field of bladder cancer].Der Urologe. Ausg. A · 2016Article
- Emerging immunotherapies for bladder cancer.Current opinion in oncology · 2015Review
- Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity.Nature reviews. Cancer · 2015Review
- Genetic variations rs11892031 and rs401681 are associated with bladder cancer risk in a Chinese population.International journal of molecular sciences · 2014Article
- The post GWAS era: strategies to identify gene-gene and gene-environment interactions in urinary bladder cancer.EXCLI journal · 2014Article
- Impact of urinary bladder cancer risk variants on prognosis and survival.EXCLI journal · 2014Article
- Highlight report: Functional consequences of urinary bladder cancer risk variants.EXCLI journal · 2013Article
- Genetic susceptibility and environmental risk factors in bladder cancer: Evidence from the UK biobank.Bladder cancer (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies (GWAS) have been successful in the identification of the several urinary bladder cancer (UBC) susceptibility loci, pointing towards novel genes involved in tumor development. Despite that, functional characterization of the identified variants remains challenging, as they mostly map to poorly understood, non-coding regions. Recently, two of the UBC risk variants (PSCA and UGT1A) were confirmed to have functional consequences. They were shown to modify bladder cancer risk by influencing gene expression in an allele-specific manner. Although the role of the other UBC risk variants is unknown, it can be hypothesized-based on studies from different cancer types-that they influence cancer susceptibility by alterations in regulatory networks. The insight into UBC heritability gained through GWAS and further functional studies can impact on cancer prevention and screening, as well as on the development of new biomarkers and future personalized therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.