ArticleIEEE transactions on bio-medical engineering2013
Assessing the Progression of Ventilator-Induced Lung Injury in Mice.
Article in IEEE transactions on bio-medical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Computer model-based injury prediction and evaluation of lung function in mice with acute and ventilator-induced lung injuries.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- The fix is not yet in: recommendation for fixation of lungs within physiological/pathophysiological volume range in preclinical pulmonary structure-function studies.American journal of physiology. Lung cellular and molecular physiology · 2024Review
- Computational lung modelling in respiratory medicine.Journal of the Royal Society, Interface · 2022Review
- PEEP/ FIO2 ARDSNet Scale Grouping of a Single Ventilator for Two Patients: Modeling Tidal Volume Response.Respiratory care · 2020Article
- Modeling Lung Derecruitment in VILI Due to Fluid-Occlusion: The Role of Emergent Behavior.Frontiers in physiology · 2020Article
- Using injury cost functions from a predictive single-compartment model to assess the severity of mechanical ventilator-induced lung injuries.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- The micromechanics of lung alveoli: structure and function of surfactant and tissue components.Histochemistry and cell biology · 2018Review
- Alveolar Micromechanics in Bleomycin-induced Lung Injury.American journal of respiratory cell and molecular biology · 2018Article
- Ventilator-induced lung injury and lung mechanics.Annals of translational medicine · 2018Review
- Linking lung function to structural damage of alveolar epithelium in ventilator-induced lung injury.Respiratory physiology & neurobiology · 2018Article
- Alveolar leak develops by a rich-get-richer process in ventilator-induced lung injury.PloS one · 2018Article
- Dynamic Mechanical Interactions Between Neighboring Airspaces Determine Cyclic Opening and Closure in Injured Lung.Critical care medicine · 2017Article
- Strain heterogeneity in the injured lung: cause or consequence?Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Predicting ventilator-induced lung injury using a lung injury cost function.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Variable Ventilation as a Diagnostic Tool for the Injured Lung.IEEE transactions on bio-medical engineering · 2015Article
- Computational Models of Ventilator Induced Lung Injury and Surfactant Dysfunction.Drug discovery today. Disease models · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Patients with acute respiratory distress syndrome receiving mechanical ventilation typically experience repetitive closure (derecruitment) and subsequent reopening (recruitment) of airways and alveoli. This can lead, over time, to further ventilator-induced lung injury (VILI). Recruitment and derecruitment (R/D) thus reflect both the current level of lung injury and the risk for sustaining further injury. Accordingly, we investigated how the dynamics of R/D are altered as VILI develops following application of high tidal volume ventilation in initially healthy mice. R/D occurring on subsecond timescales was assessed from the shape of the pressure-volume ( PV) loop measured during a single large breath. R/D occurring on a timescale of minutes was evaluated via a derecruitability test in which we tracked the progressive increases in lung elastance occurring during periods of mechanical ventilation immediately following a recruitment maneuver. The degrees of R/D occurring on these different times scales were strongly correlated. To interpret these findings in quantitative terms, we developed a computational model of the lung in which changes in lung volume occurred both via R/D and distention of already open lung units. Fitting this model to measured PV loops indicates that VILI causes R/D both to increase and to occur at progressively higher pressures, and that the lung tissue that remains open during the breath becomes progressively more overdistended. We conclude that the dynamic PV loop in conjunction with our computational model can be used to assess the current injury state of the lung as well as its likelihood of sustaining further VILI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.