Evidence map›Paper›PMID 23751777›Full record

ReviewGastroenterology2013

Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics.

Nicholas T Ventham, Nicholas A Kennedy, Elaine R Nimmo, Jack Satsangi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  6. Pooled it
  7. Pooled it
  8. Review
  9. Article
  10. GPR55 negatively regulates CD8Journal of molecular histology · 2026
    Article
  11. Article
  12. Foods (Basel, Switzerland) · 2026
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. The Effect of GB1 on DSS-Induced Colitis in WT and Nlrp3International journal of molecular sciences · 2025
    Article
  18. Review
  19. Review
  20. Article

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicholas T VenthamGastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland. nventham@staffmail.ed.ac.uk
Nicholas A Kennedy
Elaine R Nimmo
Jack Satsangi

Funding

Chief Scientist Office CZB/4/540Chief Scientist Office ETM/137Chief Scientist Office ETM/75Medical Research Council G0600329Medical Research Council G0800675Medical Research Council G0800759Wellcome Trust 097943
6 · The paper itself

Abstract

In the past decade, there have been fundamental advances in our understanding of genetic factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and ulcerative colitis. The latest international collaborative studies have brought the number of IBD susceptibility gene loci to 163. However, genetic factors account for only a portion of overall disease variance, indicating a need to better explore gene-environment interactions in the development of IBD. Epigenetic factors can mediate interactions between the environment and the genome; their study could provide new insight into the pathogenesis of IBD. We review recent progress in identification of genetic factors associated with IBD and discuss epigenetic mechanisms that could affect development and progression of IBD.

Indexed as

Epigenesis, GeneticColitis, UlcerativeCrohn DiseaseEpigenomicsGenetic Predisposition to DiseaseHumansCDCpGCrohn’s diseaseCrohn’s Diseasecytosine-guanine dinucleotidesDNA MethylationDNA methyltransferaseDNMTEpigeneticsepigenome-wide methylation association studiesEWASgenome-wide association studiesGWASHATHDACHDACihistone acetyl transferasehistone deacetylasehistone deacetylatase inhibitorsIBDILinflammatory bowel diseaseinterleukinmessenger RNAmicroRNAmiRmRNANF-κBnuclear factor κBPBMCperipheral blood mononuclear cellsingle nucleotide polymorphismSNPThT-helperTNFtumor necrosis factorUCulcerative colitisUlcerative Colitis

Identifiers

PMID23751777
PMCPMC3919211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.