ReviewCold Spring Harbor perspectives in medicine2013
Structure and function of the mucus clearance system of the lung.
Review in Cold Spring Harbor perspectives in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Oscillating Positive Expiratory Pressure (OPEP) Therapy in Bronchiectasis and Chronic Obstructive Pulmonary Disease (COPD): A Narrative Review of Clinical Studies.Pulmonary therapy · 2026Pooled it
- Chest physiotherapy for pneumonia in children.The Cochrane database of systematic reviews · 2019Pooled it
- Non-pharmaceutical management of respiratory morbidity in children with severe global developmental delay.The Cochrane database of systematic reviews · 2014Pooled it
- Cilia-independent gas-liquid transport, a third mechanism mediating airway mucus clearance.The Journal of clinical investigation · 2026Article
- Soft Artificial Ciliary Brush with Integrated Haptic Feedback for Efficient Airway Mucus Cleaning.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2026Article
- Association of Peak Expiratory Flow with Pulmonary Fungal Infection in Hospitalized Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Single-Center Retrospective Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Optimized Whole-Mount Fluorescence Staining Protocol for Pulmonary Toxicity Evaluation Using Mouse Respiratory Epithelia.Methods and protocols · 2025Article
- The virology of Omicron: pathophysiology, immune regulation, and clinical impact of SARS-CoV-2 sub variants.Virology journal · 2025Review
- Effect of positive end-expiratory pressure on risk of microaspiration and ventilator-associated pneumonia in mechanically ventilated ICU patients: a prospective study.Journal of cardiothoracic surgery · 2025Article
- Nanoparticle-Based Pulmonary Immune Engineering.Annual review of chemical and biomolecular engineering · 2025Review
- The Oral Microbiome and Systemic Health: Bridging the Gap Between Dentistry and Medicine.Cureus · 2025Review
- A Novel Medical Device for Airway Clearance.Journal of clinical medicine · 2025Article
- Effectiveness of mechanical vibration-assisted sputum clearance in pediatric pneumonia: a randomized controlled trial with development of an intelligent parameter optimization model.Frontiers in pediatrics · 2025Article
- Article
- Computational modeling of cough-induced droplets and mucosal film dynamics in the upper airway for pulmonary disease classification.Frontiers in physiology · 2025Article
- NLRP3 regulates epithelial barrier integrity and protects from airway hyperresponsiveness in experimental allergic asthma.Frontiers in immunology · 2025Article
- Nonpharmacological Treatment for Nontuberculous Mycobacterial Pulmonary Disease.Tuberculosis and respiratory diseases · 2024Article
- Article
- Mechanotransduction: Forcing a change in metabolism.Current opinion in cell biology · 2023Review
- Metabolic reprogramming in response to cell mechanics.Biology of the cell · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cystic fibrosis (CF), a defect in ion transport results in thick and dehydrated airway mucus, which is difficult to clear, making such patients prone to chronic inflammation and bacterial infections. Physiotherapy using a variety of airway clearance techniques (ACTs) represents a key treatment regime by helping clear the airways of thickened, adhered, mucus and, thus, reducing the impact of lung infections and improving lung function. This article aims to bridge the gap between our understanding of the physiological effects of mechanical stresses elicited by ACTs on airway epithelia and the reported effectiveness of ACTs in CF patients. In the first part of this review, the effects of mechanical stress on airway epithelia are discussed in relation to changes in ion transport and stimulation in airway surface layer hydration. The second half is devoted to detailing the most commonly used ACTs to stimulate the removal of mucus from the airways of patients with CF.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.