ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2013
Cryptic B cell response to renal transplantation.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02294032 (The Role of B Cells in Kidney Allograft Dysfunction), which is not on this map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of B Cells in Kidney Allograft Dysfunction
Who cites it
28 citing papers in PubMed.
- Evolving Therapeutic Approaches for Treatment of Antibody-Mediated Rejection in Renal Allograft Recipients.Results and problems in cell differentiation · 2026Review
- Accommodation in allogeneic and xenogeneic organ transplantation: Prevalence, impact, and implications for monitoring and for therapeutics.Human immunology · 2023Article
- Regional delivery of immunosuppression for transplantation of vascularized composite allografts: opportunities near and far.Annals of translational medicine · 2021Article
- IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity.JCI insight · 2021Article
- Approaches for Controlling Antibody-Mediated Allograft Rejection Through Targeting B Cells.Frontiers in immunology · 2021Review
- Impact of Immunoglobulin M-Type Donor-Specific Human Leukocyte Antigen-Antibody Levels in Supernatants from Cultured Peripheral Blood Mononuclear Cells as Predictors of Antibody-Mediated Rejection.Pathogens (Basel, Switzerland) · 2020Article
- The five dimensions of B cell tolerance.Immunological reviews · 2019Review
- Non-canonical B cell functions in transplantation.Human immunology · 2019Review
- B cells as organizers of immunity in transplantation.Human immunology · 2019Article
- An Easy and Sensitive Method to Profile the Antibody Specificities of HLA-specific Memory B Cells.Transplantation · 2019Article
- Measuring alloreactive B cell responses in transplant recipients.Current transplantation reports · 2019Article
- Article
- Toward a solution for cardiac failure in the newborn.Xenotransplantation · 2018Review
- T Follicular Regulatory Cells and Antibody Responses in Transplantation.Transplantation · 2018Review
- Autologous Mesenchymal Stromal Cells Prevent Transfusion-elicited Sensitization and Upregulate Transitional and Regulatory B Cells.Transplantation direct · 2018Article
- Accommodation in ABO-incompatible organ transplants.Xenotransplantation · 2018Review
- Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans.Transplantation · 2017Review
- Accommodation and related conditions in vascularized composite allografts.Current opinion in organ transplantation · 2017Review
- Monitoring alloimmune response in kidney transplantation.Journal of nephrology · 2017Review
- The Impact of Donor-Specific Anti-Human Leukocyte Antigen (HLA) Antibody Rebound on the Risk of Antibody Mediated Rejection in Sensitized Kidney Transplant Recipients.Annals of transplantation · 2017Article
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Authors and funding
6 authors.
Funding
Abstract
Transplantation reliably evokes allo-specific B cell and T cell responses in mice. Yet, human recipients of kidney transplants with normal function usually exhibit little or no antibody specific for the transplant donor during the early weeks and months after transplantation. Indeed, the absence of antidonor antibodies is taken to reflect effective immunosuppressive therapy and to predict a favorable outcome. Whether the absence of donor-specific antibodies reflects absence of a B cell response to the donor, tolerance to the donor or immunity masked by binding of donor-specific antibodies to the graft is not known. To distinguish between these possibilities, we devised a novel ELISPOT, using cultured donor, recipient and third-party fibroblasts as targets. We enumerated donor-specific antibody-secreting cells in the blood of nine renal allograft recipients with normal kidney function before and after transplantation. Although none of the nine subjects had detectable donor-specific antibodies before or after transplantation, all exhibited increases in the frequency of donor-specific antibody-secreting cells eight weeks after transplantation. The responses were directed against the donor HLA-class I antigens. The increase in frequency of donor-specific antibody-secreting cells after renal transplantation indicates that B cells respond specifically to the transplant donor more often than previously thought.
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Registered trials
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