ArticleClinical and experimental immunology2013
Glomerular mannose-binding lectin deposition is a useful prognostic predictor in immunoglobulin A nephropathy.
Article in Clinical and experimental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 30 citations in OpenAlex.
- Complement and kidney diseases: unlocking the opportunity of targeted treatments for glomerular diseases, including IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2026Review
- HDAC9-mediated deacetylation of CALML6 promotes excessive proliferation of glomerular mesangial cells in IgA nephropathy.Clinical and experimental nephrology · 2025Article
- Urine complement-related proteins in IgA nephropathy and IgA vasculitis nephritis, possible biomarkers of disease activity.Clinical kidney journal · 2025Article
- C4d, rather than C3d and C5b-9, Is Associated with Graft Loss in Recurrent IgA Deposition after Kidney Transplantation.American journal of nephrology · 2024Article
- Complements and Their Role in Systemic Disorders.Cureus · 2024Review
- Review
- Challenges in IgA Nephropathy Management: An Era of Complement Inhibition.Kidney international reports · 2023Review
- Characteristics and renal survival of patients with lupus nephritis with glomerular immunoglobulin GLupus science & medicine · 2022Article
- Glomerular C4 deposition and glomerulosclerosis predict worse renal outcomes in Chinese patients with IgA nephropathy.Renal failure · 2020Article
- Complement activation is associated with crescent formation in IgA nephropathy.Virchows Archiv : an international journal of pathology · 2020Article
- Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study.BMC nephrology · 2019Article
- Comprehensive evaluation of the significance of immunofluorescent findings on clinicopathological features in IgA nephropathy.Clinical and experimental nephrology · 2019Article
- Absence of the Lectin Activation Pathway of Complement Ameliorates Proteinuria-Induced Renal Injury.Frontiers in immunology · 2019Article
- Increased C4 and decreased C3 levels are associated with a poor prognosis in patients with immunoglobulin A nephropathy: a retrospective study.BMC nephrology · 2017Article
- Immunoglobulin A nephropathy: a pathophysiology view.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Review
- Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways.Kidney international reports · 2016Review
- Idiopathic membranous nephropathy and IgG4: an interesting relationship.Clinical nephrology · 2014Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is accumulating evidence to support a hypothesis of the activation of the lectin complement pathway in immunoglobulin A nephropathy (IgAN). The glomerular deposition of mannose-binding lectin (MBL), an initiator of the lectin pathway, has been identified, but its clinical significance has not been defined consistently. The aim of the present study was to investigate the value of glomerular MBL deposition as a useful histological biomarker in evaluating the severity and predicting the prognosis of IgAN. We included all consecutive patients with biopsy-proven primary IgAN from December 2008 to July 2010. Renal deposition of MBL was detected by immunofluorescence. The biopsy material from 131 patients (72 men) was thus used for MBL staining. The deposition of MBL was observed in a predominantly mesangial pattern in 45 patients (34·35%), which presented as global or segmental deposition. Compared with the patients without glomerular MBL deposition, those with glomerular MBL deposition had more severe proteinuria, decreased renal function, lower levels of serum albumin and a greater possibility of hypertension at the time of renal biopsy; they had more severe histological changes according to the Oxford classification (i.e. mesangial hypercellularity, segmental glomerulosclerosis, endocapillary hypercellularity and tubular atrophy/interstitial fibrosis), and their ratio presented an increase as the histopathological phenotypes segregated according to Lee's classification; furthermore, the follow-up data demonstrated that they had a lower renal remission rate. In conclusion, glomerular MBL deposition may predict a poor prognosis, and thus can be a new prognostic factor in IgA nephropathy.
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