Observational studyHPB : the official journal of the International Hepato Pancreato Biliary Association2013
Dynamic nature of organ failure in severe acute pancreatitis: the impact of persistent and deteriorating organ failure.
Observational study in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Trial
- High-dose intravenous vitamin C reduce C-reactive protein levels, fluid retention, and APACHE II scores in patients with moderately severe acute pancreatitis: a prospective, randomized, double-blinded, placebo-controlled study.Annals of intensive care · 2025Article
- Effect of high-dose intravenous vitamin C therapy on the prognosis in patients with moderately severe and severe acute pancreatitis: protocol of a prospective, randomized, double-blinded, placebo-controlled study.Frontiers in medicine · 2023Article
- Dynamic changes in the pancreatitis activity scoring system during hospital course in a multicenter, prospective cohort.Journal of gastroenterology and hepatology · 2021Article
- Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome.World journal of gastroenterology · 2021Article
- Mortality in acute pancreatitis with persistent organ failure is determined by the number, type, and sequence of organ systems affected.United European gastroenterology journal · 2021Article
- Dynamic Nomogram for Predicting Thrombocytopenia in Adults with Acute Pancreatitis.Journal of inflammation research · 2021Article
- Effects of Yue-Bi-Tang on water metabolism in severe acute pancreatitis rats with acute lung-kidney injury.World journal of gastroenterology · 2020Article
- Article
- Pancreatic necrosis: Complications and changing trend of treatment.World journal of gastrointestinal surgery · 2019Review
- Can Disturbed Liver Perfusion Revealed in p-CT on the First Day of Acute Pancreatitis Provide Information about the Expected Severity of the Disease?Gastroenterology research and practice · 2019Article
- Severe acute pancreatitis 5 years after pancreaticoduodenectomy: A case report.International journal of surgery case reports · 2019Article
- Article
- Perfusion-CT--Can We Predict Acute Pancreatitis Outcome within the First 24 Hours from the Onset of Symptoms?PloS one · 2016Article
- Daily estimation of the severity of organ dysfunctions in critically ill children by using the PELOD-2 score.Critical care (London, England) · 2015Article
- Significance of resistin expression in acute pancreatitis.Experimental and therapeutic medicine · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsIn acute pancreatitis (AP), patients with persistent organ failure [POF, duration of organ failure (OF) ≥48 h] and transient organ failure (TOF, duration of OF <48 h) have different outcomes. We have compared the clinical course and outcome of patients with severe AP (SAP) with TOF and POF in the first week of hospitalization as well as the impact of change in the OF score in the first week on patient outcome.
methodsConsecutive patients with SAP were evaluated for OF and its dynamics during the first week of hospitalization. The modified multiple organ failure score (MOFS) was used to identify OF, grade its severity and monitor its progression. The clinical course and outcome of patients were studied.
resultsOf 114 patients, mean age 39.2 ± 13.7 years, 37 (32.5%) patients had no OF, 34 (29.8%) had TOF and 43(37.7%) had POF. Patients with POF had the higher infected necrosis, increased requirement for percutaneous drain placement, surgery and higher mortality as compared with those with TOF. The odds ratio for mortality with persistent and deteriorating OF was 26.2 [confidence interval (CI) 5.1-134.9] compared with only persistent OF.
conclusionThe dynamics of OF in the first week of SAP predicts the clinical course and outcome. Persistent and deteriorating OF indicates a poor outcome.
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