ArticlePhysiological reports2013
Mental Stress Elicits Sustained and Reproducible Increases in Skin Sympathetic Nerve Activity.
Article in Physiological reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Simultaneous noninvasive recording of electrocardiogram and skin sympathetic nerve activity (neuECG).Nature protocols · 2020Trial
- Sympathetic neural reactivity to mental stress in humans: test-retest reproducibility.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Trial
- Melatonin attenuates the skin sympathetic nerve response to mental stress.American journal of physiology. Heart and circulatory physiology · 2013Trial
- Cortical excitation does not drive changes in skin sympathetic nerve activity during single-pulse transcranial magnetic stimulation in humans.Experimental brain research · 2026Article
- Arterial stiffness in the context of heart rate and vasomotion during orthostatic stress and cognitive load.Frontiers in network physiology · 2026Article
- Use of Infrared Thermography and Heart Rate Variability to Evaluate Autonomic Activity in Domestic Animals.Animals : an open access journal from MDPI · 2024Review
- Skin sympathetic nerve activity in patients with chronic orthostatic intolerance.Heart rhythm · 2022Article
- Mitigating Initial Orthostatic Hypotension: Mechanistic Roles of Muscle Contraction Versus Sympathetic Activation.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Measuring and quantifying skin sympathetic nervous system activity in humans.Journal of neurophysiology · 2017Review
- Recording sympathetic nerve activity in conscious humans and other mammals: guidelines and the road to standardization.American journal of physiology. Heart and circulatory physiology · 2017Review
- Neurovascular mechanisms underlying augmented cold-induced reflex cutaneous vasoconstriction in human hypertension.The Journal of physiology · 2017Article
- Blunted increases in skin sympathetic nerve activity are related to attenuated reflex vasodilation in aged human skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition.International journal of molecular sciences · 2016Review
- Sympathetic regulation during thermal stress in human aging and disease.Autonomic neuroscience : basic & clinical · 2016Review
- Augmented supraorbital skin sympathetic nerve activity responses to symptom trigger events in rosacea patients.Journal of neurophysiology · 2015Article
- Impaired increases in skin sympathetic nerve activity contribute to age-related decrements in reflex cutaneous vasoconstriction.The Journal of physiology · 2015Article
- Sympathoneural and adrenomedullary responses to mental stress.Comprehensive Physiology · 2015Review
- Ascorbic acid does not enhance hypoxia-induced vasodilation in healthy older men.Physiological reports · 2014Article
- Sex differences in forearm vasoconstrictor response to voluntary apnea.American journal of physiology. Heart and circulatory physiology · 2014Article
- Forearm vascular responses to mental stress in healthy older adults.Physiological reports · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mental stress (MS) is a known trigger of myocardial infarction and sudden death. By activating the sympathetic nervous system, MS may have deleterious effect on the cardiovascular system but this process is not completely understood. The primary aim of this study was to quantify the effect of MS on skin sympathetic nerve activity (SSNA). The secondary aim was to determine the reproducibility of SSNA to MS within a given day and ~1 week later. Ten subjects (26±1 yr.) performed two bouts of mental arithmetic lasting 3 min. The bouts were separated by 45 min. One week later the subjects returned to repeat MS. All experiments were conducted in the supine posture during the morning hours. To maintain neutral skin temperature, each subject wore a custom suit (34-35°C). Skin blood flow and sweat rate were measured on the dorsal foot. MS elicited a marked increase in SSNA within the first 10 s (184±42%; P<0.01) in all subjects, which was less during the remaining period of MS but remained elevated (87±20; P<0.01). The pattern of responses to MS was unchanged during the second bout (10 s, 247±55%; 3 min avg., 133±29%) and during the retest 1 week later (10 s, 196±55%; 3 min avg., 117±36%). MS did not significantly affect cutaneous vascular conductance or sweat rate during any trial. In summary, MS elicits robust and reproducible increases in SSNA in humans which may be followed over time to observe alterations in the regulation of the autonomic nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.