SynthesisPloS one2013
Performance of different scan protocols of fetal echocardiography in the diagnosis of fetal congenital heart disease: a systematic review and meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The diagnostic performance of the ductus venosus for the detection of cardiac defects in the first trimester: a systematic review and diagnostic test accuracy meta-analysis.Archives of gynecology and obstetrics · 2023Pooled it
- Diagnostic Value of Fetal Echocardiography for Congenital Heart Disease: A Systematic Review and Meta-Analysis.Medicine · 2015Pooled it
- First-Trimester Assessment of the Extended Fetal Cardiovascular System Using the CASSEAL 3 × 3 Framework: Feasibility, Reproducibility and Diagnostic Performance.Journal of cardiovascular development and disease · 2026Article
- The Three-Y and Trachea View (3Y + T): A Conceptual Extension of the Three-Vessel and Trachea View for Comprehensive Fetal Echocardiographic Assessment.Diagnostics (Basel, Switzerland) · 2026Review
- Screening for Structural Heart Defects: A Single-Center Retrospective Cost Analysis for Fetal Echocardiography in Adults with Congenital Heart Disease.Pediatric cardiology · 2026Article
- Role of artificial intelligence in congenital heart disease.World journal of clinical pediatrics · 2025Review
- Isolated Mild Fetal Tricuspid Regurgitation in Low-Risk Pregnancies: An Incidental Doppler Finding or a Marker of Postnatal Cardiac Risk?Children (Basel, Switzerland) · 2025Article
- Feasibility of a Standardised Mid-Trimester Ultrasound Protocol: A National Multicenter Study.BJOG : an international journal of obstetrics and gynaecology · 2025Observational
- Artificial intelligence in fetal echocardiography: Recent advances and future prospects.International journal of cardiology. Heart & vasculature · 2024Review
- A comparative study of fetal cardiovascular assessment: utilizing Doppler ultrasound gated MRI and echocardiography with detailed analysis using five axial views.Frontiers in cardiovascular medicine · 2024Article
- First Trimester Tricuspid Regurgitation: Clinical Significance.Current cardiology reviews · 2023Review
- Early Detection of Isolated Severe Congenital Heart Defects Is Associated with a Lower Threshold to Terminate the Pregnancy.Fetal diagnosis and therapy · 2023Article
- Factors causing timely referral for fetal echocardiography in the final diagnosis of congenital heart malformations: A cross-sectional study.International journal of reproductive biomedicine · 2022Article
- Can Fetal Echocardiographic Measurements of the Left Ventricular Outflow Tract Angle Detect Fetuses with Conotruncal Cardiac Anomalies?Diagnostics (Basel, Switzerland) · 2021Article
- Usefulness of Postnatal Echocardiography in Patients with Down Syndrome with Normal Fetal Echocardiograms.Pediatric cardiology · 2019Article
- Fetal echocardiography (ECHO) in assessment of structural heart defects in congenital diaphragmatic hernia patients: Is early postnatal ECHO necessary for ECMO candidacy?Journal of pediatric surgery · 2019Article
- A novel ultrasound scanning approach for evaluating femoral cartilage defects of the knee: comparison with routine magnetic resonance imaging.Journal of orthopaedic surgery and research · 2018Article
- Autoimmune-associated Congenital Heart Block: A New Insight in Fetal Life.Chinese medical journal · 2017Review
- Prospective evaluation of the fetal heart using Fetal Intelligent Navigation Echocardiography (FINE).Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe rapid progress in fetal echocardiography has lead to early detection of congenital heart diseases. Increasing evidences have shown that prenatal diagnosis could be life saving in certain cases. However, there is no agreement on which protocol is most adaptive diagnostic one. Thus, we use meta-analysis to conduct a pooled performance test on 5 diagnostic protocols.
methodsWe searched PUBMED, EMBASE, the Cochrane Central Register of Controlled Trials and WHO clinical trails registry center to identify relevant studies up to August, 2012. We performed meta-analysis in a fixed/random-effect model using Meta-disc 1.4. We used STATA 11.0 to estimate the publication bias and SPSS 17.0 to evaluate variance.
resultsWe use results from 81 studies in 63 articles to analyze the pooled accuracy. The overall performance of pooled sensitivities of spatiotemporal image correlation (STIC), extend cardiac echography examination (ECEE) and 4 chambers view + outflow tract view + 3 vessels and trachea view (4 CV+OTV+3 VTV) were around 0.90, which was significant higher than that of 4 chambers view + outflow tract view or 3 vessels and trachea view (4 CV+OTV/3 VTV) and 4 chambers view (4 CV). Unfortunately the pooled specificity of STIC was 0.92, which was significant lower than that of other 4 protocols which reached at 1.00. The area under the summary receiver operating characteristic curves value of STIC, ECEE, 4 CV+OTV+3 VTV, 4 CV+OTV/3 VTV and 4 CV were 0.9700, 0.9971, 0.9983, 0.9929 and 0.9928 respectively.
conclusionThese results suggest a great diagnostic potential for fetal echocardiography detection as a reliable method of fetal congenital heart disease. But at least 3 sections view (4 CV, OTV and 3 VTV) should be included in scan protocol, while the STIC can be used to provide more information for local details of defects, and can not be used to make a definite diagnosis alone with its low specificity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.