Evidence map›Paper›PMID 23750235›Full record

ArticlePloS one2013

Adaptability and persistence of the emerging pathogen Bordetella petrii.

Adrian M Zelazny, Li Ding, Joanna B Goldberg, Lilia A Mijares, Sean Conlan, Patricia S Conville, Frida Stock, Samuel J Ballentine, Kenneth N Olivier, Elizabeth P Sampaio and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Non-classicalThe Journal of international medical research · 2024
    Article
  3. Clinical microbiology reviews · 2023
    Review
  4. Article
  5. Conquering the host:Frontiers in microbiology · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Septic arthritis and osteomyelitis due to Bordetella petrii.Journal of clinical microbiology · 2015
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Adrian M ZelaznyLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. azelazny@mail.nih.gov
Li Ding
Joanna B Goldberg
Lilia A Mijares
Sean Conlan
Patricia S Conville
Frida Stock
Samuel J Ballentine
Kenneth N Olivier
Elizabeth P Sampaio
Patrick R Murray
Steven M Holland
National Institutes of Health Clinical Center · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USNational Human Genome Research Institute · USUniversity of Virginia Health System · US

Funding

Molecular and Virulence Traits of Bacteria & Fungi Causing Persistent InfectionsZIACL080013 · CLC · CLINICAL CENTER · PI ZELAZNY, ADRIAN MARCELO · 2009 to 2025
$0k
Intramural NIH HHS
6 · The paper itself

Abstract

The first described, environmentally isolated, Bordetella petrii was shown to undergo massive genomic rearrangements in vitro. More recently, B. petrii was isolated from clinical samples associated with jaw, ear bone, cystic fibrosis and chronic pulmonary disease. However, the in vivo consequences of B. petrii genome plasticity and its pathogenicity remain obscure. B. petrii was identified from four sequential respiratory samples and a post-mortem spleen sample of a woman presenting with bronchiectasis and cavitary lung disease associated with nontuberculous mycobacterial infection. Strains were compared genetically, phenotypically and by antibody recognition from the patient and from inoculated mice. The successive B. petrii strains exhibited differences in growth, antibiotic susceptibility and recognition by the patient's antibodies. Antibodies from mice inoculated with these strains recapitulated the specificity and strain dependent response that was seen with the patient's serum. Finally, we characterize one strain that was poorly recognized by the patient's antibodies, due to a defect in the lipopolysaccharide O-antigen, and identify a mutation associated with this phenotype. We propose that B. petrii is remarkably adaptable in vivo, providing a possible connection between immune response and bacterial evasion and supporting infection persistence.

Indexed as

Adaptation, PhysiologicalAdaptive ImmunityAnimalsAntibodies, BacterialBordetellaFemaleHumansImmune EvasionImmunizationLung DiseasesMiceMiddle AgedMutationO AntigensSequence AnalysisAntibodies, BacterialO Antigens

Identifiers

PMID23750235
PMCPMC3672207
OpenAlexW1974446523

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.