ArticleFrontiers in immunology2013
Biophysical description of multiple events contributing blood leukocyte arrest on endothelium.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Nanoscopic Characterization of Cell Migration under Flow Using Optical and Electron Microscopy.Analytical chemistry · 2023Article
- Mechanosurveillance: Tiptoeing T Cells.Frontiers in immunology · 2022Review
- Adhesive dynamics simulations quantitatively predict effects of kindlin-3 deficiency on T-cell homing.Integrative biology : quantitative biosciences from nano to macro · 2019Article
- Halloysite Nanotube Coatings Suppress Leukocyte Spreading.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- IL-5 induces suspended eosinophils to undergo unique global reorganization associated with priming.American journal of respiratory cell and molecular biology · 2014Article
- Arrest chemokines.Frontiers in immunology · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood leukocytes have a remarkable capacity to bind to and stop on specific blood vessel areas. Many studies have disclosed a key role of integrin structural changes following the interaction of rolling leukocytes with surface-bound chemoattractants. However, the functional significance of structural data and mechanisms of cell arrest are incompletely understood. Recent experiments revealed the unexpected complexity of several key steps of cell-surface interaction: (i) ligand-receptor binding requires a minimum amount of time to proceed and this is influenced by forces. (ii) Also, molecular interactions at interfaces are not fully accounted for by the interaction properties of soluble molecules. (iii) Cell arrest depends on nanoscale topography and mechanical properties of the cell membrane, and these properties are highly dynamic. Here, we summarize these results and we discuss their relevance to recent functional studies of integrin-receptor association in cells from a patient with type III leukocyte adhesion deficiency. It is concluded that an accurate understanding of all physical events listed in this review is needed to unravel the precise role of the multiple molecules and biochemical pathway involved in arrest triggering.
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Registered trials
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