ArticleMacromolecules2013
A critical evaluation of random copolymer mimesis of homogeneous antimicrobial peptides.
Article in Macromolecules, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Drp1 Proteins Released from Hydrolysis-Driven Scaffold Disassembly Trigger Nucleotide-Dependent Membrane Remodeling to Promote Scission.Journal of the American Chemical Society · 2025Article
- Saddle curvature association of nsP1 facilitates the replication complex assembly of Chikungunya virus in cells.Nature communications · 2025Article
- Smart Materials Design for Antibacterial Application.Pharmaceutical nanotechnology · 2025Review
- How do cyclic antibiotics with activity against Gram-negative bacteria permeate membranes? A machine learning informed experimental study.Biochimica et biophysica acta. Biomembranes · 2020Article
- Chemokine CCL28 Is a Potent Therapeutic Agent for Oropharyngeal Candidiasis.Antimicrobial agents and chemotherapy · 2020Article
- Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1.ACS infectious diseases · 2020Article
- Decoupling the Functional Roles of Cationic and Hydrophobic Groups in the Antimicrobial and Hemolytic Activities of Methacrylate Random Copolymers.Biomacromolecules · 2018Article
- What Can Pleiotropic Proteins in Innate Immunity Teach Us about Bioconjugation and Molecular Design?Bioconjugate chemistry · 2018Review
- What can machine learning do for antimicrobial peptides, and what can antimicrobial peptides do for machine learning?Interface focus · 2017Review
- Molecular Motor Dnm1 Synergistically Induces Membrane Curvature To Facilitate Mitochondrial Fission.ACS central science · 2017Article
- Direct Antimicrobial Activity of IFN-β.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Calcium and Magnesium Ions Are Membrane-Active against Stationary-Phase Staphylococcus aureus with High Specificity.Scientific reports · 2016Article
- Helical antimicrobial polypeptides with radial amphiphilicity.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Pentobra: A Potent Antibiotic with Multiple Layers of Selective Antimicrobial Mechanisms against Propionibacterium Acnes.The Journal of investigative dermatology · 2015Article
- Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.Journal of the American Chemical Society · 2014Article
- Amphiphilic macromolecules on cell membranes: from protective layers to controlled permeabilization.The Journal of membrane biology · 2014Review
- Article
- Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptides.Biochimica et biophysica acta · 2014Article
- Antimicrobial peptides and induced membrane curvature: geometry, coordination chemistry, and molecular engineering.Current opinion in solid state & materials science · 2013Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Polymeric synthetic mimics of antimicrobial peptides (SMAMPs) have recently demonstrated similar antimicrobial activity as natural antimicrobial peptides (AMPs) from innate immunity. This is surprising, since polymeric SMAMPs are heterogeneous in terms of chemical structure (random sequence) and conformation (random coil), in contrast to defined amino acid sequence and intrinsic secondary structure. To understand this better, we compare AMPs with a 'minimal' mimic, a well characterized family of polydisperse cationic methacrylate-based random copolymer SMAMPs. Specifically, we focus on a comparison between the quantifiable membrane curvature generating capacity, charge density, and hydrophobicity of the polymeric SMAMPs and AMPs. Synchrotron small angle x-ray scattering (SAXS) results indicate that typical AMPs and these methacrylate SMAMPs generate similar amounts of membrane negative Gaussian curvature (NGC), which is topologically necessary for a variety of membrane-destabilizing processes. Moreover, the curvature generating ability of SMAMPs is more tolerant of changes in the lipid composition than that of natural AMPs with similar chemical groups, consistent with the lower specificity of SMAMPs. We find that, although the amount of NGC generated by these SMAMPs and AMPs are similar, the SMAMPs require significantly higher levels of hydrophobicity and cationic charge to achieve the same level of membrane deformation. We propose an explanation for these differences, which has implications for new synthetic strategies aimed at improved mimesis of AMPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.