ArticleJournal of bacteriology2013
The Streptococcus mutans aminotransferase encoded by ilvE is regulated by CodY and CcpA.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Branched-Chain Amino Acids Mediate the Regulation of SACE_Lrp on the Aminotransferase IlvE Involved in Erythromycin Biosynthesis in Saccharopolyspora erythraea.Microbial biotechnology · 2026Article
- Pyruvate metabolism is involved in adaptability and cariogenicity ofJournal of oral microbiology · 2026Review
- Regulation of the pleiotropic transcriptional regulator CodY on the conversion of branched-chain amino acids into branched-chain aldehydes inApplied and environmental microbiology · 2023Article
- CcpA and CodY Regulate CRISPR-Cas System ofMicrobiology spectrum · 2023Article
- Repression of the TreR transcriptional regulator in Streptococcus mutans by the global regulator, CcpA.FEMS microbiology letters · 2021Article
- Identification of conditionally essential genes forVirulence · 2020Article
- Regulation of cid and lrg expression by CodY in Streptococcus mutans.MicrobiologyOpen · 2020Article
- Comparative transcriptomic analysis ofPeerJ · 2020Article
- Characterization of LrgAB as a stationary phase-specific pyruvate uptake system in Streptococcus mutans.BMC microbiology · 2019Article
- Synthetic Simplification of Carolacton Enables Chemical Genetic Studies inACS infectious diseases · 2019Article
- Identification, Expression and Activity of Candidate Nitrite Reductases From OrangeFrontiers in microbiology · 2019Article
- Review
- Impact of growth pH and glucose concentrations on the CodY regulatory network in Streptococcus salivarius.BMC genomics · 2018Article
- CcpA and CodY Coordinate Acetate Metabolism in Streptococcus mutans.Applied and environmental microbiology · 2017Article
- Acid-adaptive mechanisms of Streptococcus mutans-the more we know, the more we don't.Molecular oral microbiology · 2017Review
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- The CodY regulator is essential for virulence in Streptococcus suis serotype 2.Scientific reports · 2016Article
- The GlnR Regulon in Streptococcus mutans Is Differentially Regulated by GlnR and PmrA.PloS one · 2016Article
- Functional profiling in Streptococcus mutans: construction and examination of a genomic collection of gene deletion mutants.Molecular oral microbiology · 2015Article
- NanI Sialidase, CcpA, and CodY Work Together To Regulate Epsilon Toxin Production by Clostridium perfringens Type D Strain CN3718.Journal of bacteriology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The aminotransferase IlvE was implicated in the acid tolerance response of Streptococcus mutans when a mutation in its gene resulted in an acid-sensitive phenotype (B. Santiago, M. MacGilvray, R. C. Faustoferri, and R. G. Quivey, Jr., J. Bacteriol. 194:2010-2019, 2012). The phenotype suggested that amino acid metabolism is important for acid adaptation, as turnover of branched-chain amino acids (bcAAs) could provide important signals to modulate expression of genes involved in the adaptive process. Previous studies have demonstrated that ilvE is regulated in response to the external pH, though the mechanism is not yet established. CodY and CcpA have been shown to regulate expression of branched-chain amino acid biosynthetic genes, suggesting that the ability to sense carbon flow and the nutritional state of the cell also plays a role in the regulation of ilvE. Electrophoretic mobility shift assays using the ilvE promoter and a purified recombinant CodY protein provided evidence of the physical interaction between CodY and ilvE. In order to elucidate the signals that contribute to ilvE regulation, cat reporter fusions were utilized. Transcriptional assays demonstrated that bcAAs are signaling molecules involved in the repression of ilvE through regulation of CodY. In a codY deletion background, ilvE transcription was elevated, indicating that CodY acts a repressor of ilvE transcription. Conversely, in a ccpA deletion background, ilvE transcription was reduced, showing that CcpA activated ilvE transcription. The effects of both regulators were directly relevant for transcription of ilvE under conditions of acid stress, demonstrating that both regulators play a role in acid adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.