ArticleJournal of bacteriology2013
Quorum sensing regulatory cascades control Vibrio fluvialis pathogenesis.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Quorum sensing regulators AphA and HapR differentially regulate fluvibactin biosynthesis inFrontiers in microbiology · 2026Article
- Characterization of quorum regulatory small RNAs in an emerging pathogenEmerging microbes & infections · 2024Article
- Virulence, antibiotic resistance phenotypes and molecular characterisation of Vibrio furnissii isolates from patients with diarrhoea.BMC infectious diseases · 2024Article
- Facilitating nitrification and biofilm formation of Vibrio sp. by N-acyl-homoserine lactones in high salinity environment.Bioprocess and biosystems engineering · 2024Article
- VfqI-VfqR quorum sensing circuit modulates type VI secretion system VflT6SS2 inBiochemistry and biophysics reports · 2022Article
- Accurate Identification of Diverse N-acyl Homoserine Lactones in Marine Vibrio fluvialis by UHPLC-MS/MS.Current microbiology · 2022Article
- Population genomics of the food-borne pathogenMicrobial genomics · 2022Article
- CqsA/LuxS-HapR Quorum sensing circuit modulates type VI secretion system VflT6SS2 inEmerging microbes & infections · 2021Article
- Direct Cobamide Remodeling via Additional Function of Cobamide Biosynthesis Protein CobS from Vibrio cholerae.Journal of bacteriology · 2021Article
- Siderophore piracy enhancesMicrobiology (Reading, England) · 2020Article
- "In-Group" Communication in MarineFrontiers in cellular and infection microbiology · 2018Review
- Article
- Characterization of N-Acyl Homoserine Lactones in Vibrio tasmaniensis LGP32 by a Biosensor-Based UHPLC-HRMS/MS Method.Sensors (Basel, Switzerland) · 2017Article
- Functional Characterization and Conditional Regulation of the Type VI Secretion System inFrontiers in microbiology · 2017Article
- Detection of Diverse N-Acyl-Homoserine Lactones inFrontiers in microbiology · 2017Article
- Quorum Sensing Inhibition and Structure-Activity Relationships of β-Keto Esters.Molecules (Basel, Switzerland) · 2016Article
- Article
- A critical role for hemolysin in Vibrio fluvialis-induced IL-1β secretion mediated by the NLRP3 inflammasome in macrophages.Frontiers in microbiology · 2015Article
- Identification of genetic bases of vibrio fluvialis species-specific biochemical pathways and potential virulence factors by comparative genomic analysis.Applied and environmental microbiology · 2014Article
- Vibrio fluvialis: an emerging human pathogen.Frontiers in microbiology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Quorum sensing (QS) is a process by which individual bacteria are able to communicate with one another, thereby enabling the population as a whole to coordinate gene regulation and subsequent phenotypic outcomes. Communication is accomplished through production and detection of small molecules in the extracellular milieu. In many bacteria, particularly Vibrio species, multiple QS systems result in multiple signals, as well as cross talk between systems. In this study, we identify two QS systems in the halophilic enteric pathogen Vibrio fluvialis: one acyl-homoserine lactone (AHL) based and one CAI-1/AI-2 based. We show that a LuxI homolog, VfqI, primarily produces 3-oxo-C10-HSL, which is sensed by a LuxR homolog, VfqR. VfqR-AHL is required to activate vfqI expression and autorepress vfqR expression. In addition, we have shown that similar to that in V. cholerae and V. harveyi, V. fluvialis produces CAI-1 and AI-2 signal molecules to activate the expression of a V. cholerae HapR homolog through LuxO. Although VfqR-AHL does not regulate hapR expression, HapR can repress vfqR transcription. Furthermore, we found that QS in V. fluvialis positively regulates production of two potential virulence factors, an extracellular protease and hemolysin. QS also affects cytotoxic activity against epithelial tissue cultures. These data suggest that V. fluvialis integrates QS regulatory pathways to play important physiological roles in pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.