ArticleThe Plant cell2013
Hierarchical nuclear and cytoplasmic genetic architectures for plant growth and defense within Arabidopsis.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Genome-wide association studies identify loci controlling specialized seed metabolites in Arabidopsis.Plant physiology · 2024Article
- Genetics as a key to improving crop photosynthesis.Journal of experimental botany · 2022Article
- Article
- Reciprocal cybrids reveal how organellar genomes affect plant phenotypes.Nature plants · 2020Article
- Plant trichomes and a single gene GLABRA1 contribute to insect community composition on field-grown Arabidopsis thaliana.BMC plant biology · 2019Article
- The plastid and mitochondrial genomes of Eucalyptus grandis.BMC genomics · 2019Article
- Comparison of the Relative Potential for Epigenetic and Genetic Variation To Contribute to Trait Stability.G3 (Bethesda, Md.) · 2018Article
- Inheritance patterns in metabolism and growth in diallel crosses of Arabidopsis thaliana from a single growth habitat.Heredity · 2018Article
- Genetic dissection of metabolite variation in Arabidopsis seeds: evidence for mQTL hotspots and a master regulatory locus of seed metabolism.Journal of experimental botany · 2017Article
- An Integrative Genetic Study of Rice Metabolism, Growth and Stochastic Variation Reveals Potential C/N Partitioning Loci.Scientific reports · 2016Article
- Genome-Wide Association Mapping and Genomic Prediction Elucidate the Genetic Architecture of Morphological Traits in Arabidopsis.Plant physiology · 2016Article
- Cytonuclear interactions affect adaptive traits of the annual plant Arabidopsis thaliana in the field.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Isolate Dependency of Brassica rapa Resistance QTLs to Botrytis cinerea.Frontiers in plant science · 2016Article
- Integrative Approaches to Enhance Understanding of Plant Metabolic Pathway Structure and Regulation.Plant physiology · 2015Article
- Natural Variation of Plant Metabolism: Genetic Mechanisms, Interpretive Caveats, and Evolutionary and Mechanistic Insights.Plant physiology · 2015Article
- Quantitative Variation in Responses to Root Spatial Constraint within Arabidopsis thaliana.The Plant cell · 2015Article
- Exploiting Differential Gene Expression and Epistasis to Discover Candidate Genes for Drought-Associated QTLs in Arabidopsis thaliana.The Plant cell · 2015Article
- Natural diversity in daily rhythms of gene expression contributes to phenotypic variation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Higher-order genetic interactions and their contribution to complex traits.Trends in genetics : TIG · 2015Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand how genetic architecture translates between phenotypic levels, we mapped the genetic architecture of growth and defense within the Arabidopsis thaliana Kas × Tsu recombinant inbred line population. We measured plant growth using traditional size measurements and size-corrected growth rates. This population contains genetic variation in both the nuclear and cytoplasmic genomes, allowing us to separate their contributions. The cytoplasmic genome regulated a significant variance in growth but not defense, which was due to cytonuclear epistasis. Furthermore, growth adhered to an infinitesimal model of genetic architecture, while defense metabolism was more of a moderate-effect model. We found a lack of concordance between quantitative trait loci (QTL) regulating defense and those regulating growth. Given the published evidence proving the link between glucosinolates and growth, this is likely a false negative result caused by the limited population size. This size limitation creates an inability to test the entire potential genetic landscape possible between these two parents. We uncovered a significant effect of glucosinolates on growth once we accounted for allelic differences in growth QTLs. Therefore, other growth QTLs can mask the effects of defense upon growth. Investigating direct links across phenotypic hierarchies is fraught with difficulty; we identify issues complicating this analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.