ArticleThe Journal of comparative neurology2013
Withdrawal and restoration of central vagal afferents within the dorsal vagal complex following subdiaphragmatic vagotomy.
Article in The Journal of comparative neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.Cell reports · 2021Trial
- PLX3397-Induced Microglial Ablation Alters Adipose Tissue Accumulation in a Male-Female-Dependent Manner Under High-Energy-Diet Feeding.Nutrients · 2025Article
- Functionally distinct evoked and spontaneous neurotransmission operate via a shared pool of synaptic vesicles in viscerosensory afferents.The Journal of physiology · 2025Article
- Vagotomy blunts cardiorespiratory responses to vagal afferent stimulation via pre- and postsynaptic effects in the nucleus tractus solitarii.The Journal of physiology · 2024Article
- A Critical Involvement of Glutamatergic Neurons in the Anterior Insular Cortex for Subdiaphragmatic Vagotomy-induced Analgesia.Experimental neurobiology · 2023Article
- Intrinsic positional memory guides target-specific axon regeneration in the zebrafish vagus nerve.Development (Cambridge, England) · 2021Article
- Microbiota's Role in Diet-Driven Alterations in Food Intake: Satiety, Energy Balance, and Reward.Nutrients · 2021Review
- Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release.Cell reports · 2021Article
- Unilateral vagotomy alters astrocyte and microglial morphology in the nucleus tractus solitarii of the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Role of the Autonomic Nervous System in Mechanism of Energy and Glucose Regulation Post Bariatric Surgery.Frontiers in neuroscience · 2021Review
- Gut microbiota composition modulates inflammation and structure of the vagal afferent pathway.Physiology & behavior · 2020Article
- Consumption of a high energy density diet triggers microbiota dysbiosis, hepatic lipidosis, and microglia activation in the nucleus of the solitary tract in rats.Nutrition & diabetes · 2020Article
- Roux‑en‑Y gastric bypass surgery triggers rapid DNA fragmentation in vagal afferent neurons in rats.Acta neurobiologiae experimentalis · 2019Article
- Gut adaptation after metabolic surgery and its influences on the brain, liver and cancer.Nature reviews. Gastroenterology & hepatology · 2018Review
- Mechanisms of vagal plasticity influencing feeding behavior.Brain research · 2018Review
- Selective Vagotomy Worsens Glucose Control After Ileal Transposition.Obesity surgery · 2018Article
- Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders.Frontiers in psychiatry · 2018Review
- Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity.Physiology & behavior · 2017Article
- Energy-dense diet triggers changes in gut microbiota, reorganization of gut‑brain vagal communication and increases body fat accumulation.Acta neurobiologiae experimentalis · 2017Article
- The Role of the Vagal Nucleus Tractus Solitarius in the Therapeutic Effects of Obesity Surgery and Other Interventional Therapies on Type 2 Diabetes.Obesity surgery · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Vagotomy, a severing of the peripheral axons of the vagus nerve, has been extensively utilized to determine the role of vagal afferents in viscerosensory signaling. Vagotomy is also an unavoidable component of some bariatric surgeries. Although it is known that peripheral axons of the vagus nerve degenerate and then regenerate to a limited extent following vagotomy, very little is known about the response of central vagal afferents in the dorsal vagal complex to this type of damage. We tested the hypothesis that vagotomy results in the transient withdrawal of central vagal afferent terminals from their primary central target, the nucleus of the solitary tract (NTS). Sprague-Dawley rats underwent bilateral subdiaphragmatic vagotomy and were sacrificed 10, 30, or 60 days later. Plastic changes in vagal afferent fibers and synapses were investigated at the morphological and functional levels by using a combination of an anterograde tracer, synapse-specific markers, and patch-clamp electrophysiology in horizontal brain sections. Morphological data revealed that numbers of vagal afferent fibers and synapses in the NTS were significantly reduced 10 days following vagotomy and were restored to control levels by 30 days and 60 days, respectively. Electrophysiology revealed transient decreases in spontaneous glutamate release, glutamate release probability, and the number of primary afferent inputs. Our results demonstrate that subdiaphragmatic vagotomy triggers transient withdrawal and remodeling of central vagal afferent terminals in the NTS. The observed vagotomy-induced plasticity within this key feeding center of the brain may be partially responsible for the response of bariatric patients following gastric bypass surgery.
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