Evidence map›Paper›PMID 23749451›Full record

ArticleG3 (Bethesda, Md.)2013

Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells identifies novel wing genes.

Daniel M Ibrahim, Brian Biehs, Thomas B Kornberg, Ansgar Klebes

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Daniel M IbrahimFreie Universität Berlin, Institut für Biologie, Genetik, 14195 Berlin, Germany.
Brian Biehs
Thomas B Kornberg
Ansgar Klebes
University of California, San Francisco · USFreie Universität Berlin · DE

Funding

MOLECULAR MECHANISMS IN DEVELOPMENTR01GM030637 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORNBERG, THOMAS B. · 1985 to 2017
$6.8M
NIGMS NIH HHS GM030637NIGMS NIH HHS R01 GM030637
6 · The paper itself

Abstract

Signaling between cells in the anterior (A) and posterior (P) compartments directs Drosophila wing disc development and is dependent on expression of the homeodomain transcription factor Engrailed (En) in P cells. Downstream of en, posteriorly expressed Hedgehog (Hh) protein signals across the A/P border to establish a developmental organizer that directs pattern formation and growth throughout the wing primordium. Here we extend investigations of the processes downstream of en by using expression array analysis to compare A and P cells. A total of 102 candidate genes were identified that express differentially in the A and P compartments; four were characterized: Stubble (Sb) expression is restricted to A cells due to repression by en. CG15905, CG16884; CG10200/hase und igel (hui) are expressed in A cells downstream of Hh signaling; and RNA interference for hui, Stubble, and CG16884 revealed that each is essential to wing development.

Indexed as

AnimalsChromosome MappingDrosophilaDrosophila ProteinsGene Expression Regulation, DevelopmentalHedgehog ProteinsHomeodomain ProteinsImaginal DiscsMembrane ProteinsOligonucleotide Array Sequence AnalysisRNA InterferenceSerine EndopeptidasesSignal TransductionTranscription FactorsWings, AnimalDrosophila ProteinsEn protein, DrosophilaHedgehog Proteinshh protein, DrosophilaHomeodomain ProteinsMembrane Proteinssb protein, DrosophilaSerine EndopeptidasesTranscription Factorsanteroposterior compartment borderengrailedexpression microarrayhedgehogpattern formation

Identifiers

PMID23749451
PMCPMC3737175
OpenAlexW2170400950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.