ArticleHippocampus2013
Volumetric analysis of medial temporal lobe subregions in developmental amnesia using high-resolution magnetic resonance imaging.
Article in Hippocampus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 83 citations in OpenAlex.
- Developing an Anatomically Valid Segmentation Protocol for Anterior Regions of the Medial Temporal Lobe for Neurodegenerative Diseases.Hippocampus · 2025Article
- Effects of Early Midlife Ovarian Removal on Medial Temporal Lobe Gray Matter Volume and Recognition Memory.Hippocampus · 2025Article
- The interactive effects of divided attention and semantic elaboration on associative recognition memory: an fMRI study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Effect of Segmentation Method on Medial Temporal Lobe Subregion Volumes in Aging.Human brain mapping · 2024Article
- Postmortem imaging reveals patterns of medial temporal lobe vulnerability to tau pathology in Alzheimer's disease.Nature communications · 2024Article
- Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories.Hippocampus · 2024Article
- Disturbed sleep is associated with reduced verbal episodic memory and entorhinal cortex volume in younger middle-aged women with risk-reducing early ovarian removal.Frontiers in endocrinology · 2023Article
- Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology.Acta neuropathologica communications · 2021Article
- Getting better without memory.Social cognitive and affective neuroscience · 2020Article
- Characterization of hippocampal subfields using ex vivo MRI and histology data: Lessons for in vivo segmentation.Hippocampus · 2020Article
- Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease.Human brain mapping · 2019Article
- Article
- Performance of semi-automated hippocampal subfield segmentation methods across ages in a pediatric sample.NeuroImage · 2019Article
- Volumetric comparison of hippocampal subfields extracted from 4-minute accelerated vs. 8-minute high-resolution T2-weighted 3T MRI scans.Brain imaging and behavior · 2018Article
- Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain.eLife · 2018Article
- Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Anterolateral Entorhinal Cortex Volume Predicted by Altered Intra-Item Configural Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A protocol for manual segmentation of medial temporal lobe subregions in 7 Tesla MRI.NeuroImage. Clinical · 2017Article
- Segmenting subregions of the human hippocampus on structural magnetic resonance image scans: An illustrated tutorial.Brain and neuroscience advances · 2017Article
- Hippocampal and diencephalic pathology in developmental amnesia.Cortex; a journal devoted to the study of the nervous system and behavior · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
There is great interest in the cognitive consequences of hippocampal volume loss in developmental amnesia (DA). In many DA cases, volume loss occurs before the hippocampus is fully developed, and yet little is known about the locus, extent, and distribution of damage in these cases. We used high-resolution MRI to manually segment the medial temporal lobe (MTL) subregions in H.C., an adult with DA, and a group of sex-, age- and education-matched control participants (n = 10). The hippocampus was defined and divided into anterior (head) and posterior (body and tail) segments. Within the body of the hippocampus, the subregions (CA1 , DG/CA2/3 , and subiculum) were defined. Finally, the entorhinal (ERC), perirhinal (PRC), and parahippocampal (PHC) cortices were segmented. Anterior hippocampus was reduced bilaterally and posterior hippocampus was significantly reduced on the right. In the body of the hippocampus, all three subregions were reduced in the left hemisphere, whereas CA1 and subiculum were reduced in the right hemisphere. No group differences were observed in the PRC and ERC, whereas left PHC volume was marginally increased in H.C. compared to controls. These results can be used to inform patterns of spared and impaired cognitive abilities in DA and perhaps in amnesia more generally.
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