Evidence map›Paper›PMID 23749111›Full record

ReviewInternational journal of molecular sciences2013

UV radiation and the skin.

John D'Orazio, Stuart Jarrett, Alexandra Amaro-Ortiz, Timothy Scott

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 814 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
814citing papers in PubMed, 5 pooled it
33.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

814 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,859 citations in OpenAlex.

  1. Pooled it
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  5. Pooled it
  6. Trial
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  10. Article
  11. Cancer Incidence Among Swedish Seafarers Between 1985 and 2020.American journal of industrial medicine · 2026
    Article
  12. Review
  13. Article
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  16. Nutrients · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Protective Effects of a Mixture of Propolis andInternational journal of molecular sciences · 2026
    Article

754 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

John D'OrazioGraduate Center for Toxicology and the Departments of Pediatrics, Biomedical and Molecular Pharmacology and Physiology, Markey Cancer Center, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA. jdorazio@uky.edu.
Stuart Jarrett
Alexandra Amaro-Ortiz
Timothy Scott
The Graduate Center, CUNY · USMarkey Cancer Center · USUniversity of Kentucky · US

Funding

The role of Mc1r in melanocytic UV-induced DNA damage and repair responsesR01CA131075 · NCI · UNIVERSITY OF KENTUCKY · PI D'ORAZIO, JOHN A · 2010 to 2020
$3.3M
NCI NIH HHS R01 CA131075NCI NIH HHS R01 CA131075-02S1
6 · The paper itself

Abstract

UV radiation (UV) is classified as a "complete carcinogen" because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. However, UV also benefits human health by mediating natural synthesis of vitamin D and endorphins in the skin, therefore UV has complex and mixed effects on human health. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy. UV is epidemiologically and molecularly linked to the three most common types of skin cancer, basal cell carcinoma, squamous cell carcinoma and malignant melanoma, which together affect more than a million Americans annually. Genetic factors also influence risk of UV-mediated skin disease. Polymorphisms of the melanocortin 1 receptor (MC1R) gene, in particular, correlate with fairness of skin, UV sensitivity, and enhanced cancer risk. We are interested in developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance.

Indexed as

Ultraviolet RaysAnimalsHumansMelaninsOxidative StressSkinSkin NeoplasmsSkin PigmentationMelanins

Identifiers

PMID23749111
PMCPMC3709783
OpenAlexW2029390954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.