ReviewCellular and molecular life sciences : CMLS2014
Wnt and lithium: a common destiny in the therapy of nervous system pathologies?
Review in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review).Molecular medicine reports · 2026Review
- Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes.Scientific reports · 2025Article
- Effects of Adolescent Social Isolation on PFC's β-Catenin Levels and Anxiety-Like Behaviors in Male and Female Rats: Study of the Role of Dopaminergic D2 Receptors.Journal of molecular neuroscience : MN · 2025Article
- In Vitro Models of Cardiovascular Disease: Embryoid Bodies, Organoids and Everything in Between.Biomedicines · 2024Review
- Integrated co-expression network analysis uncovers novel tissue-specific genes in major depressive disorder and bipolar disorder.Frontiers in psychiatry · 2022Article
- Scalp Electroacupuncture Promotes Angiogenesis after Stroke in Rats by Activation of Wnt/Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Methylome-wide association study of different responses to risperidone in schizophrenia.Frontiers in pharmacology · 2022Article
- Nucleosome assembly protein 1-like 5 alleviates Alzheimer's disease-like pathological characteristics in a cell model.Frontiers in molecular neuroscience · 2022Article
- A GWAS top hit for circulating leptin is associated with weight gain but not with leptin protein levels in lithium-augmented patients with major depression.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Article
- Insights into the Regulation on Proliferation and Differentiation of Stem Leydig Cells.Stem cell reviews and reports · 2021Review
- Genome-wide DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia in the Chinese Han population.Molecular psychiatry · 2021Article
- Review
- New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?Neural regeneration research · 2020Review
- High Dosage Lithium Treatment Induces DNA Damage and p57International journal of molecular sciences · 2020Article
- Anticancer effect of the traditional Chinese medicine herb Maytenus compound via the EGFR/PI3K/AKT/GSK3β pathway.Translational cancer research · 2019Article
- A novel tumor suppressor SPINK5 targets Wnt/β-catenin signaling pathway in esophageal cancer.Cancer medicine · 2019Article
- Decrease of GSK-3β Activity in the Anterior Cingulate Cortex ofFrontiers in cellular neuroscience · 2019Article
- Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder.Translational psychiatry · 2018Article
- Lithium Reversibly Inhibits Schwann Cell Proliferation and Differentiation Without Inducing Myelin Loss.Molecular neurobiology · 2017Article
- Gene expression associated with suicide attempts in US veterans.Translational psychiatry · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wnt signaling is required for neurogenesis, the fate of neural progenitors, the formation of neuronal circuits during development, neuron positioning and polarization, axon and dendrite development and finally for synaptogenesis. This signaling pathway is also implicated in the generation and differentiation of glial cells. In this review, we describe the mechanisms of action of Wnt signaling pathways and their implication in the development and correct functioning of the nervous system. We also illustrate how a dysregulated Wnt pathway could lead to psychiatric, neurodegenerative and demyelinating pathologies. Lithium, used for the treatment of bipolar disease, inhibits GSK3β, a central enzyme of the Wnt/β-catenin pathway. Thus, lithium could, to some extent, mimic Wnt pathway. We highlight the possible dialogue between lithium therapy and modulation of Wnt pathway in the treatment of the diseases of the nervous system.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.