ArticleIranian biomedical journal2013
Identification and characterization of metallo-β-lactamases producing Pseudomonas aeruginosa clinical isolates in University Hospital from Zanjan Province, Iran.
Article in Iranian biomedical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 33 citations in OpenAlex.
- Molecular characterization of extended-spectrum β-lactamase (ESBL) and virulent genes in multidrug-resistant Escherichia coli isolated from pharmaceutical and environmental Wastewaters in Dhaka, Bangladesh.Scientific reports · 2026Article
- Multidrug Resistance Profiles and Resistance Mechanisms to β-Lactams and Fluoroquinolones in Bacterial Isolates from Hospital Wastewater in Bangladesh.Current issues in molecular biology · 2023Article
- Molecular Characterization of Gene-Mediated Resistance and Susceptibility of ESKAPE Clinical Isolates toEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Prevalence of β-lactamase genes, class 1 integrons, major virulence factors and clonal relationships of multidrug-resistantIranian journal of basic medical sciences · 2019Article
- Genotyping ofIranian journal of pharmaceutical research : IJPR · 2019Article
- Evaluation of multidrug resistance patterns in siderophore-producingNew microbes and new infections · 2018Article
- The threat of carbapenem-resistant gram-negative bacteria in a Middle East region.Infection and drug resistance · 2018Review
- Prevalence of Clinically Isolated Metallo-beta-lactamase-producingIranian journal of pathology · 2018Review
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- Evaluation of Metallo-β-Lactamase-Production and Carriage ofArchives of trauma research · 2016Article
- Detecting the frequency of aminoglycoside modifying enzyme encoding genes among clinical isolates of methicillin-resistant Staphylococcus aureus.BioImpacts : BI · 2015Article
- Clonal Relatedness among Imipenem-Resistant Pseudomonas aeruginosa Isolated from ICU-Hospitalized Patients.Critical care research and practice · 2015Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundInfectious by Pseudomonas aeruginosa has spread worldwide and metallo-beta-lactamases (MBL) are being reported with increasing frequency. The aim of this study was to investigate the antibiotic susceptibility and distribution of blaVIM and blaIMP genes in P. aeruginosa isolates from Zanjan Province of Iran.
methodsA total of 70 P. aeruginosa isolates were identified from patients admitted at intensive care units. The antimicrobial susceptibility was tested by disk diffusion (Kirby-Bauer) method and for production of MBL using double-disk synergy test (DDST). After DNA extraction, the presence of blaVIM and blaIMP genes and class 1 integron were detected by PCR.
resultsMost of the isolates were resistant to meropenem, cefotaxime and imipenem (IPM). Also, 44/70 (62.85%) IPM resistant isolates were confirmed by DDST. Of the 44 clinical isolates, 41 (93%) isolates showed MIC≥4 µg/ml for IPM. Based on the DDST results, 36 (87.8%) were confirmed to be MBL producers. PCR amplification showed that 23/41 (56%) carried blaVIM and 10/41 (24.3%) possessed blaIMP gene. Also, 31/44 (70.5%) isolates contained class 1 integron gene.
conclusionOur results highlight that the genes for Verona integron-encoded metallo-β-lactamase, IPM β-lactamases and class 1 integrons were predominantly present among the IPM-resistant P. aeruginosa tested in our province and also the frequency of blaVIM type is higher than blaIMP. This is the first report of P. aeruginosa strains producing blaIMP with high frequency from Zanjan province of Iran.
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