ArticleLasers in medical science2015
Antimicrobial photodynamic therapy against pathogenic bacterial suspensions and biofilms using chloro-aluminum phthalocyanine encapsulated in nanoemulsions.
Article in Lasers in medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 68 citations in OpenAlex.
- Antimicrobial photodynamic therapy against multidrug-resistant Staphylococcus aureus using aluminum chloride phthalocyanine nanoemulsion: in vitro and in vivo studies.Folia microbiologica · 2025Article
- Nanocarrier-based Drug Delivery Systems to Enhance Antimicrobial Photodynamic Therapy in Dental Applications: A Review.AAPS PharmSciTech · 2025Review
- Nonlinear van't Hoff Behavior in the Interaction of Two Water-Soluble Porphyrins with Bovine Serum Albumin (BSA).ACS omega · 2024Article
- Efficiency of the photodynamic therapy on viability of Streptococcus mutans in the oral cavity using chitosan nanoparticles: an in vitro study.Lasers in medical science · 2024Article
- Nanomaterial-based drug-delivery system as an aid to antimicrobial photodynamic therapy in treating oral biofilm.Future microbiology · 2024Review
- Antimicrobial Photodynamic Therapy againstMicroorganisms · 2023Article
- Photoinactivation of multispecies cariogenic biofilm mediated by aluminum phthalocyanine chloride encapsulated in chitosan nanoparticles.Lasers in medical science · 2022Article
- Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms.International journal of molecular sciences · 2022Review
- Photophysical characterization and in vitro anti-leishmanial effect of 5,10,15,20-tetrakis(4-fluorophenyl) porphyrin and the metal (Zn(II), Sn(IV), Mn(III) and V(IV)) derivatives.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Turning Photons into Drugs: Phthalocyanine-Based Photosensitizers as Efficient Photoantimicrobials.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Monosubstituted tricationic Zn(II) phthalocyanine enhances antimicrobial photodynamic inactivation (aPDI) of methicillin-resistantEmerging microbes & infections · 2020Article
- In Vitro Anti-Leishmanial Effect of Metallic Meso-Substituted Porphyrin Derivatives againstMolecules (Basel, Switzerland) · 2020Article
- An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics-A Critical Review.Journal of functional biomaterials · 2019Article
- Antimicrobial Photodynamic Therapy to Control Clinically Relevant Biofilm Infections.Frontiers in microbiology · 2018Review
- Encapsulation of curcumin in polymeric nanoparticles for antimicrobial Photodynamic Therapy.PloS one · 2017Article
- Photodynamic inactivation of pathogenic species Pseudomonas aeruginosa and Candida albicans with lutetium (III) acetate phthalocyanines and specific light irradiation.Lasers in medical science · 2016Article
- Antimicrobial photodynamic therapy for inactivation of biofilms formed by oral key pathogens.Frontiers in microbiology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial photodynamic therapy represents an alternative method of killing resistant pathogens. Efforts have been made to develop delivery systems for hydrophobic drugs to improve the photokilling. This study evaluated the photodynamic effect of chloro-aluminum phthalocyanine (ClAlPc) encapsulated in nanoemulsions (NE) on methicillin-susceptible and methicillin-resistant Staphylococcus aureus suspensions and biofilms. Suspensions and biofilms were treated with different delivery systems containing ClAlPc. After the pre-incubation period, the drug was washed-out and irradiation was performed with LED source (660 ± 3 nm). Negative control samples were not exposed to ClAlPc or light. For the suspensions, colonies were counted (colony-forming units per milliliter (CFU/mL)). The metabolic activity of S. aureus suspensions and biofilms were evaluated by the XTT assay. The efficiency was dependent on the delivery system, superficial load and light dose. Cationic NE-ClAlPc and free-ClAlPc caused photokilling of the both strains of S. aureus. For biofilms, cationic NE-ClAlPc reduced cell metabolism by 80 and 73% of susceptible and resistant strains, respectively. Although anionic NE-ClAlPc caused a significant CFU/ml reduction for MSSA and MRSA, it was not capable of reducing MRSA biofilm metabolism. This therapy may represent an alternative treatment for eradicating resistant strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.