Evidence map›Paper›PMID 23748627›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA

Automated identification of drug and food allergies entered using non-standard terminology.

Richard H Epstein, Paul St Jacques, Michael Stockin, Brian Rothman, Jesse M Ehrenfeld, Joshua C Denny

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. AllergyMap: An Open Source Corpus of Allergy Mention Normalizations.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2020
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Food entries in a large allergy data repository.Journal of the American Medical Informatics Association : JAMIA · 2016
    Article
  15. Desiderata for computable representations of electronic health records-driven phenotype algorithms.Journal of the American Medical Informatics Association : JAMIA · 2015
    Article
  16. Article
  17. Induced lexico-syntactic patterns improve information extraction from online medical forums.Journal of the American Medical Informatics Association : JAMIA
    Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Richard H EpsteinDepartment of Anesthesiology, Jefferson Medical College, Philadelphia, Pennsylvania, USA.
Paul St Jacques
Michael Stockin
Brian Rothman
Jesse M Ehrenfeld
Joshua C Denny

Funding

Pharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4M
NHLBI NIH HHS U19 HL065962
6 · The paper itself

Abstract

objectiveAn accurate computable representation of food and drug allergy is essential for safe healthcare. Our goal was to develop a high-performance, easily maintained algorithm to identify medication and food allergies and sensitivities from unstructured allergy entries in electronic health record (EHR) systems. MATERIALS AND

methodsAn algorithm was developed in Transact-SQL to identify ingredients to which patients had allergies in a perioperative information management system. The algorithm used RxNorm and natural language processing techniques developed on a training set of 24 599 entries from 9445 records. Accuracy, specificity, precision, recall, and F-measure were determined for the training dataset and repeated for the testing dataset (24 857 entries from 9430 records).

resultsAccuracy, precision, recall, and F-measure for medication allergy matches were all above 98% in the training dataset and above 97% in the testing dataset for all allergy entries. Corresponding values for food allergy matches were above 97% and above 93%, respectively. Specificities of the algorithm were 90.3% and 85.0% for drug matches and 100% and 88.9% for food matches in the training and testing datasets, respectively. DISCUSSION: The algorithm had high performance for identification of medication and food allergies. Maintenance is practical, as updates are managed through upload of new RxNorm versions and additions to companion database tables. However, direct entry of codified allergy information by providers (through autocompleters or drop lists) is still preferred to post-hoc encoding of the data. Data tables used in the algorithm are available for download.

conclusionsA high performing, easily maintained algorithm can successfully identify medication and food allergies from free text entries in EHR systems.

Indexed as

AlgorithmsDrug HypersensitivityElectronic Health RecordsFood HypersensitivityData MiningHumansMedical Records Systems, ComputerizedAllergiesElectronic health recordsElectronic medical recordsHypersensitivityNatural language processingRxNorm

Identifiers

PMID23748627
PMCPMC3756276

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.