ArticleNature cell biology2013
A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes.
Article in Nature cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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Who cites it
105 citing papers in PubMed.
- Data modeling the interplay between single-cell shape, single-cell protein expression, and tissue state.Cell reports methods · 2026Article
- Single-cell morphodynamical trajectories enable prediction of gene expression accompanying cell state change.Cell systems · 2026Article
- Decoding the Role of Caveolin-1 in Morphological Diversity and Self-Renewal of Breast Cancer Cells.Cell proliferation · 2026Article
- Self-Organizing Ovarian Somatic Organoids Preserve Cellular Heterogeneity and Reveal Cellular Contributions to Ovarian Aging.Aging cell · 2026Article
- Attention-based deep learning for accurate cell image analysis.Scientific reports · 2025Article
- Cell-mechanical parameter estimation from 1D cell trajectories using simulation-based inference.PloS one · 2025Article
- An innovative cellular medicine approach via the utilization of novel nanotechnology-based biomechatronic platforms as a label-free biomarker for early melanoma diagnosis.Scientific reports · 2024Article
- Systematic data analysis pipeline for quantitative morphological cell phenotyping.Computational and structural biotechnology journal · 2024Review
- Integrating single-cell transcriptomics with cellular phenotypes: cell morphology, CaBiophysical reviews · 2024Review
- Spherical harmonics analysis reveals cell shape-fate relationships in zebrafish lateral line neuromasts.Development (Cambridge, England) · 2024Article
- Understanding Cell Differentiation Through Single-Cell Approaches: Conceptual Challenges of the Systemic Approach.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Transcriptional state dynamics lead to heterogeneity and adaptive tumor evolution in urothelial bladder carcinoma.Communications biology · 2023Article
- Cell state transitions: catch them if you can.Development (Cambridge, England) · 2023Article
- Hyaluronic acid modified carbon nanotubes using for photothermal therapy by promoting apoptosis of nasopharyngeal carcinoma cells.Frontiers in bioengineering and biotechnology · 2023Article
- In vivo 3D profiling of site-specific human cancer cell morphotypes in zebrafish.The Journal of cell biology · 2022Article
- Self-supervised classification of subcellular morphometric phenotypes reveals extracellular matrix-specific morphological responses.Scientific reports · 2022Article
- Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging.Nature communications · 2022Article
- Reconstructing data-driven governing equations for cell phenotypic transitions: integration of data science and systems biology.Physical biology · 2022Review
- ARHGEF9 regulates melanoma morphogenesis in environments with diverse geometry and elasticity by promoting filopodial-driven adhesion.iScience · 2022Article
- Cell Architecture-Dependent Constraints: Critical Safeguards to Carcinogenesis.International journal of molecular sciences · 2022Review
45 more citing papers are in PubMed but not listed here.
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13 authors.
Funding
Abstract
The way in which cells adopt different morphologies is not fully understood. Cell shape could be a continuous variable or restricted to a set of discrete forms. We developed quantitative methods to describe cell shape and show that Drosophila haemocytes in culture are a heterogeneous mixture of five discrete morphologies. In an RNAi screen of genes affecting the morphological complexity of heterogeneous cell populations, we found that most genes regulate the transition between discrete shapes rather than generating new morphologies. In particular, we identified a subset of genes, including the tumour suppressor PTEN, that decrease the heterogeneity of the population, leading to populations enriched in rounded or elongated forms. We show that these genes have a highly conserved function as regulators of cell shape in both mouse and human metastatic melanoma cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.