ArticleNucleic acids research2013
Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Core enhancers of the 3'RR optimize IgH nuclear position and loop conformation for successful oriented class switch recombination.Nucleic acids research · 2024Article
- Detection of Allele-Specific 3D Chromatin Interactions Using High-Resolution In-Nucleus 4C-seq.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Contribution of Immunoglobulin Enhancers to B Cell Nuclear Organization.Frontiers in immunology · 2022Review
- Understanding three-dimensional chromatin organization in diploid genomes.Computational and structural biotechnology journal · 2021Review
- V(D)J recombination, somatic hypermutation and class switch recombination of immunoglobulins: mechanism and regulation.Immunology · 2020Review
- The Yin and Yang of RNA surveillance in B lymphocytes and antibody-secreting plasma cells.BMB reports · 2019Review
- Physiological and druggable skipping of immunoglobulin variable exons in plasma cells.Cellular & molecular immunology · 2019Article
- The Post-GWAS Era: From Association to Function.American journal of human genetics · 2018Review
- The IGH locus relocalizes to a "recombination compartment" in the perinucleolar region of differentiating B-lymphocytes.Oncotarget · 2017Article
- Article
- The IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection.Oncotarget · 2017Article
- A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production.The Journal of experimental medicine · 2016Article
- Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci.Nucleic acids research · 2016Article
- Evolution of vertebrate sex chromosomes and dosage compensation.Nature reviews. Genetics · 2016Review
- Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2.BMC genomics · 2015Article
- Article
- Article
- Independent recruitment of Igh alleles in V(D)J recombination.Nature communications · 2014Article
- fourSig: a method for determining chromosomal interactions in 4C-Seq data.Nucleic acids research · 2014Article
- Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.PLoS biology · 2014Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In developing B cells, the immunoglobulin heavy chain (IgH) locus is thought to move from repressive to permissive chromatin compartments to facilitate its scheduled rearrangement. In mature B cells, maintenance of allelic exclusion has been proposed to involve recruitment of the non-productive IgH allele to pericentromeric heterochromatin. Here, we used an allele-specific chromosome conformation capture combined with sequencing (4C-seq) approach to unambigously follow the individual IgH alleles in mature B lymphocytes. Despite their physical and functional difference, productive and non-productive IgH alleles in B cells and unrearranged IgH alleles in T cells share many chromosomal contacts and largely reside in active chromatin. In brain, however, the locus resides in a different repressive environment. We conclude that IgH adopts a lymphoid-specific nuclear location that is, however, unrelated to maintenance of allelic exclusion. We additionally find that in mature B cells-but not in T cells-the distal VH regions of both IgH alleles position themselves away from active chromatin. This, we speculate, may help to restrict enhancer activity to the productively rearranged VH promoter element.
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