ArticleMagma (New York, N.Y.)2014
In vivo chlorine and sodium MRI of rat brain at 21.1 T.
Article in Magma (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Ultra-high static magnetic fields altered the embryonic division and development in Caenorhabditis elegans via multipolar spindles.Journal of advanced research · 2025Article
- Wideband receive-coil array design using high-impedance amplifiers for broadband decoupling.Magnetic resonance in medicine · 2023Article
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- Hardware Considerations for Preclinical Magnetic Resonance of the Kidney.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Use of MRI, metabolomic, and genomic biomarkers to identify mechanisms of chemoresistance in glioma.Cancer drug resistance (Alhambra, Calif.) · 2019Review
- [Functional MRI 2.0. ²³Na and CEST imaging].Der Radiologe · 2016Review
- 30 Years of sodium/X-nuclei magnetic resonance imaging.Magma (New York, N.Y.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectMR imaging of low-gamma nuclei at the ultrahigh magnetic field of 21.1 T provides a new opportunity for understanding a variety of biological processes. Among these, chlorine and sodium are attracting attention for their involvement in brain function and cancer development. MATERIALS AND
methodsMRI of (35)Cl and (23)Na were performed and relaxation times were measured in vivo in normal rat (n = 3) and in rat with glioma (n = 3) at 21.1 T. The concentrations of both nuclei were evaluated using the center-out back-projection method.
resultsT 1 relaxation curve of chlorine in normal rat head was fitted by bi-exponential function (T 1a = 4.8 ms (0.7) T 1b = 24.4 ± 7 ms (0.3) and compared with sodium (T 1 = 41.4 ms). Free induction decays (FID) of chlorine and sodium in vivo were bi-exponential with similar rapidly decaying components of [Formula: see text] ms and [Formula: see text] ms, respectively. Effects of small acquisition matrix and bi-exponential FIDs were assessed for quantification of chlorine (33.2 mM) and sodium (44.4 mM) in rat brain.
conclusionThe study modeled a dramatic effect of the bi-exponential decay on MRI results. The revealed increased chlorine concentration in glioma (~1.5 times) relative to a normal brain correlates with the hypothesis asserting the importance of chlorine for tumor progression.
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