ArticlePediatric nephrology (Berlin, Germany)2013
The role of urinary TGF-β₁, TNF-α, IL-6 and microalbuminuria for monitoring therapy in posterior urethral valves.
Article in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Influence of genetic polymorphism in renin-angiotensin system-candidate genes on urinary trefoil family factor 3 levels in children with congenital anomalies of kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2022Article
- Urinary biomarkers as point-of-care tests for predicting progressive deterioration of kidney function in congenital anomalies of kidney and urinary tract: trefoil family factors (TFFs) as the emerging biomarkers.Pediatric nephrology (Berlin, Germany) · 2021Article
- First-year profile of biomarkers for early detection of renal injury in infants with congenital urinary tract obstruction.Pediatric nephrology (Berlin, Germany) · 2019Article
- Current strategies to predict and manage sequelae of posterior urethral valves in children.Pediatric nephrology (Berlin, Germany) · 2018Review
- Posterior urethral valve in fetuses: evidence for the role of inflammatory molecules.Pediatric nephrology (Berlin, Germany) · 2017Article
- Immunologic Effects of the Renin-Angiotensin System.Journal of the American Society of Nephrology : JASN · 2017Review
- Urinary biomarkers for renal tract malformations.Expert review of proteomics · 2016Review
- Urine interleukin-6, interleukin-8 and transforming growth factor β1 in infants with urinary tract infection and asymptomatic bacteriuria.Central-European journal of immunology · 2016Article
- Posterior urethral valve: Prognostic factors and renal outcome.Journal of Indian Association of Pediatric Surgeons · 2014Article
- Role of Urinary Transforming Growth Factor Beta-B1 and Monocyte Chemotactic Protein-1 as Prognostic Biomarkers in Posterior Urethral Valve.Journal of Indian Association of Pediatric SurgeonsArticle
- Correlation of Urinary Biomarkers (Interleukin-6, Transforming growth factor-β, E-Cadherin, and MCP-1) with Conventional Parameters of Disease Progression in Patients of Posterior Urethral Valves: A Comparative Analysis.Journal of Indian Association of Pediatric SurgeonsArticle
- Congenital Anomalies of the Kidney and Urinary Tract, Biomarkers, and Chronic Kidney Disease in Children: A Trajectory for the Surgeon-Scientists of the Next Generation.Journal of Indian Association of Pediatric SurgeonsArticle
- Role of Urinary Biomarkers (Transforming Growth Factor β1, Neutrophil Gelatinase-Associated Lipocalin, and Cystatin C) as a Prognostic Factor of Renal Outcome in the Posterior Urethral Valve.Journal of Indian Association of Pediatric SurgeonsArticle
- Evaluation of Caspase 3 Enzyme and TNF-alpha as Biomarkers in Ureteropelvic Junction Obstruction in Children- a preliminary report.Pakistan journal of medical sciencesArticle
- Genome-Wide Association Study in Craniosynostosis Condition Using Innovative Systematic Bioinformatic Analysis Tools and Techniques: Future Prospective and Clinical Practice.Journal of pediatric neurosciencesArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term renal deterioration is common in patients with posterior urethral valves (PUV), and early identification of detrimental factors can help in counselling patients as well as in guiding future therapy. The aim of our study was (1) to evaluate urinary transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) levels and microalbuminuria before and after ablation of PUV and (2) to examine the effect of early induction of angiotensin-converting enzyme inhibitors (ACE-I) on renal recovery.
methodsThe study included 30 patients with diagnosed PUV. Urinary cytokines were measured pre-operatively and post-operatively for 1 year. The study group was subdivided into two subgroups at 6 months after surgery. Group 1 included 16 patients whose urinary TGF-β1 level showed a declining trend. Group 2 included 14 patients whose urinary TGF-β1 showed a rising trend or plateaued; these patients were started on ACE-I therapy, which they received for at least 6 months.
resultsUrinary TGF-β1, TNF-α and microalbumin levels were high in patients with PUV. In Group 1 patients, urinary TGF-β1, TNF-α and microalbumin levels fell significantly following valve ablation and continued to decline for 12 months. In Group 2 patients, after an initial fall following valve ablation, urinary TGF-β1, TNF-α and microalbumin showed a continued rise until 6 months post-surgery. After ACE-I therapy, there was 53.43 % fall in urinary TGF-β1, 43.15 % fall in microalbuminuria, 28.57 % improvement in split renal function and 35.80 % improvement in GFR.
conclusionsBased on our results, urinary TGF-β1, urinary TNF-α and microalbuminuria can be used as biomarkers for the early recognition of ongoing renal damage in patients with PUV. ACE-I plays a role in retarding renal damage in these patients.
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