ArticleNature nanotechnology2013
A plasmonic 'antenna-in-box' platform for enhanced single-molecule analysis at micromolar concentrations.
Article in Nature nanotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed.
- SERS and SEF with enhancement in nanogaps: from fabrication to biosensing.Nanoscale advances · 2026Review
- Quantizing DNA Metallization For Site-Defined Growth Of Single Quantum Emitters.Small structures · 2026Article
- Single-Molecule Imaging and Spectroscopy Enables Quantification of Location-Dependent Light-Matter Interactions on Nanoantennas.Small science · 2026Article
- Mie Voids for Single-Molecule Fluorescence Enhancement in Wavelength-Scale Detection Volumes.Sensors (Basel, Switzerland) · 2025Article
- Bringing Attomolar Detection to the Point-of-Care with Nanopatterned DNA Origami Nanoantennas.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Single-Molecule Protein Interactions and Unfolding Revealed by Plasmon-Enhanced Fluorescence.Analytical chemistry · 2025Article
- Harnessing the Power of Plasmonics forACS photonics · 2025Review
- Nearfield control over magnetic light-matter interactions.Light, science & applications · 2025Article
- Plasmonic biosensors and actuators for integrated point-of-care diagnostics.Npj biosensing · 2025Review
- Advancements in SERS: Revolutionizing Biomedical Analysis and Applications.Nanotheranostics · 2025Review
- Reusable SERS Platform of Femtosecond Laser Processed Substrate for Detection of Malachite Green.Molecules (Basel, Switzerland) · 2024Article
- Hexagonal Plasmonic Arrays for High-Throughput Multicolor Single-Molecule Studies.ACS applied materials & interfaces · 2024Article
- Improvement of directivity in plasmonic nanoantennas based on structured cubic gold nanoparticles.Scientific reports · 2024Article
- Bridging Nanomanufacturing and Artificial Intelligence-A Comprehensive Review.Materials (Basel, Switzerland) · 2024Review
- Fluorescence Enhancement in Topologically Optimized Gallium Phosphide All-Dielectric Nanoantennas.Nano letters · 2024Article
- Continuous Monitoring Biosensing Mediated by Single-Molecule Plasmon-Enhanced Fluorescence in Complex Matrices.ACS nano · 2024Article
- Productive biosensing techniques empowered by all-dielectric metasurfaces.Frontiers in bioengineering and biotechnology · 2024Article
- Ultraviolet Resonant Nanogap Antennas with Rhodium Nanocube Dimers for Enhancing Protein Intrinsic Autofluorescence.ACS nano · 2023Article
- Defocused imaging-based quantification of plasmon-induced distortion of single emitter emission.Light, science & applications · 2023Article
- Strategies for Overcoming the Single-Molecule Concentration Barrier.ACS measurement science au · 2023Review
27 more citing papers are in PubMed but not listed here.
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Single-molecule fluorescence techniques are key for a number of applications, including DNA sequencing, molecular and cell biology and early diagnosis. Unfortunately, observation of single molecules by diffraction-limited optics is restricted to detection volumes in the femtolitre range and requires pico- or nanomolar concentrations, far below the micromolar range where most biological reactions occur. This limitation can be overcome using plasmonic nanostructures, which enable the confinement of light down to nanoscale volumes. Although these nanoantennas enhance fluorescence brightness, large background signals and/or unspecific binding to the metallic surface have hampered the detection of individual fluorescent molecules in solution at high concentrations. Here we introduce a novel 'antenna-in-box' platform that is based on a gap-antenna inside a nanoaperture. This design combines fluorescent signal enhancement and background screening, offering high single-molecule sensitivity (fluorescence enhancement up to 1,100-fold and microsecond transit times) at micromolar sample concentrations and zeptolitre-range detection volumes. The antenna-in-box device can be optimized for single-molecule fluorescence studies at physiologically relevant concentrations, as we demonstrate using various biomolecules.
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