Evidence map›Paper›PMID 23748186›Full record

ReviewAgeing research reviews2013

Phagocyte dysfunction, tissue aging and degeneration.

Wei Li

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ageing research reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Immunosenescence: signaling pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2025
    Review
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  20. Hematopoietic Stem Cells and the Immune System in Development and Aging.International journal of molecular sciences · 2023
    Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Wei LiBascom Palmer Eye Institute, Neuroscience Program, Dept. of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: wli@med.miami.edu.
University of Miami · US

Funding

Elucidation of Tubby and Tulp 1 Mechanisms by Comparitive Functional ProteomicsR01GM094449 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LI, WEI · 2011 to 2014
$1.1M
Unraveling the Mystery of Molecular Phagocyte Biology for MicrogliaR21HD075372 · NICHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LI, WEI · 2012 to 2013
$411k
NICHD NIH HHS R21 HD075372NICHD NIH HHS R21HD075372NIGMS NIH HHS R01 GM094449NIGMS NIH HHS R01GM094449
6 · The paper itself

Abstract

Immunologically-silent phagocytosis of apoptotic cells is critical to maintaining tissue homeostasis and innate immune balance. Aged phagocytes reduce their functional activity, leading to accumulation of unphagocytosed debris, chronic sterile inflammation and exacerbation of tissue aging and damage. Macrophage dysfunction plays an important role in immunosenescence. Microglial dysfunction has been linked to age-dependent neurodegenerations. Retinal pigment epithelial (RPE) cell dysfunction has been implicated in the pathogenesis of age-related macular degeneration (AMD). Despite several reports on the characterization of aged phagocytes, the role of phagocyte dysfunction in tissue aging and degeneration is yet to be fully appreciated. Lack of knowledge of molecular mechanisms by which aging reduces phagocyte function has hindered our capability to exploit the therapeutic potentials of phagocytosis for prevention or delay of tissue degeneration. This review summarizes our current knowledge of phagocyte dysfunction in aged tissues and discusses possible links to age-related diseases. We highlight the challenges to decipher the molecular mechanisms, present new research approaches and envisage future strategies to prevent phagocyte dysfunction, tissue aging and degeneration.

Indexed as

AgingAnimalsApoptosisCellular SenescenceHumansMacular DegenerationPhagocytesPhagocytosisRetinal Pigment EpitheliumAgingMacrophageMicrogliaPhagocyte dysfunctionPhagocytosisRetinal pigment epithelium

Identifiers

PMID23748186
PMCPMC3842398
OpenAlexW2075525665

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.