Evidence map›Paper›PMID 23748119›Full record

GuidelinePain2013

Interventional management of neuropathic pain: NeuPSIG recommendations.

Robert H Dworkin, Alec B O'Connor, Joel Kent, Sean C Mackey, Srinivasa N Raja, Brett R Stacey, Robert M Levy, Miroslav Backonja, Ralf Baron, Henning Harke and 4 more

5 registry-linked trialsOpen access · greenAbstract readGuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 199 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed, 23 pooled it
37.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03066037 completednot on this map

Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study

TypeobservationalSponsorCharite University, Berlin, GermanyRan2009 to 2016Enrolled83ConditionsChronic Pain, Trigeminal Neuralgia, Cluster Headache, Post-Zoster NeuralgiaArmsregional-anaesthesiological infiltration
NCT04648085 nacompletednot on this mapstarted 2021, after this paper: background citation

Effect of Trigeminal Nerve Stimulation on Subbasal Corneal Nerve Plexus Density and Chronic Ocular Pain in Patients With Dry Eye

TypeinterventionalSponsorInstituto de Oftalmología Fundación Conde de ValencianaRan2021 to 2021Enrolled7ConditionsDry Eye, Neuropathic Pain, Eye PainArmsTrigeminal Nerve Stimulation
NCT04735159 nacompletednot on this mapstarted 2016, after this paper: background citation

Development of a Predictive Model of Effectiveness for the Implantation of Electrical Neurostimulators in Patients With Chronic Pain Using Imaging Biomarkers Extracted From Magnetic Resonance

TypeinterventionalSponsorGeneral University Hospital of ValenciaRan2016 to 2019Enrolled60ConditionsFailed Back Surgery SyndromeArmsSCS implanted with Precision SpectraTM
NCT04835779 unknown statusnot on this mapstarted 2020, after this paper: background citation

Biometric and Biological Data for Diagnosis and Therapy of Pain Patients German: Biometrische Und Biologische Daten für Die Diagnose Und Therapie Bei Schmerzpatienten

TypeobservationalSponsorRWTH Aachen UniversityRan2020 to 2023Enrolled68ConditionsSmall Fiber Neuropathy
NCT06261801 narecruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy of Electroacupuncture Combined With Pregabalin in the Treatment of Trigeminal Herpetic Neuralgia: a Multicenter Randomized Controlled Trial Study Protocol

TypeinterventionalSponsorThe Third People's Hospital of HangzhouRan2024 to 2025Enrolled102ConditionsTrigeminal Herpetic NeuralgiaArmsMedication Group, EA Group, EA+Medication Group
3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 23 syntheses or guidelines pooled it, 449 citations in OpenAlex.

  1. Pooled it
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  7. Pooled it
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  9. Guideline
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pregabalin for neuropathic pain in adults.The Cochrane database of systematic reviews · 2019
    Pooled it
  14. Cannabis-based medicines for chronic neuropathic pain in adults.The Cochrane database of systematic reviews · 2018
    Pooled it
  15. Pooled it
  16. Tramadol for neuropathic pain in adults.The Cochrane database of systematic reviews · 2017
    Pooled it
  17. Gabapentin for chronic neuropathic pain in adults.The Cochrane database of systematic reviews · 2017
    Pooled it
  18. Morphine for chronic neuropathic pain in adults.The Cochrane database of systematic reviews · 2017
    Pooled it
  19. Methadone for neuropathic pain in adults.The Cochrane database of systematic reviews · 2017
    Pooled it
  20. Pooled it

139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Robert H DworkinDepartment of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA Department of Neurology, Center for Human Experimental Therapeutics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA University of Rochester, Rochester, NY, USA Stanford University, Palo Alto, CA, USA Johns Hopkins University, Baltimore, MD, USA Oregon Health and Science University, Portland, OR, USA Northwestern University, Chicago, IL, USA University of Wisconsin, Madison, WI, USA University of Kiel, Kiel, Germany Schmerzfachpraxis, Krefeld, Germany University of Washington, Seattle, WA, USA Universität Heidelberg, Mannheim, Germany Pain Matters, Liverpool, UK.
Alec B O'Connor
Joel Kent
Sean C Mackey
Srinivasa N Raja
Brett R Stacey
Robert M Levy
Miroslav Backonja
Ralf Baron
Henning Harke
John D Loeser
Rolf-Detlef Treede
Dennis C Turk
Christopher D Wells
Oregon Health & Science University · USUniversity of Rochester · USUniversity of Washington · USHeidelberg University · DEJohns Hopkins University · USKiel University · DENorthwestern University · USStanford University · USUniversity of Wisconsin–Madison · US

Funding

INJURY-INDUCES PAIN-- CHEMICAL MODULATION OF NOCICEPTORSR01NS026363 · NINDS · JOHNS HOPKINS UNIVERSITY · PI RAJA, SRINIVASA N. · 1989 to 2021
$6.8M
NINDS NIH HHS R01 NS026363
6 · The paper itself

Abstract

Neuropathic pain (NP) is often refractory to pharmacologic and noninterventional treatment. On behalf of the International Association for the Study of Pain Neuropathic Pain Special Interest Group, the authors evaluated systematic reviews, clinical trials, and existing guidelines for the interventional management of NP. Evidence is summarized and presented for neural blockade, spinal cord stimulation (SCS), intrathecal medication, and neurosurgical interventions in patients with the following peripheral and central NP conditions: herpes zoster and postherpetic neuralgia (PHN); painful diabetic and other peripheral neuropathies; spinal cord injury NP; central poststroke pain; radiculopathy and failed back surgery syndrome (FBSS); complex regional pain syndrome (CRPS); and trigeminal neuralgia and neuropathy. Due to the paucity of high-quality clinical trials, no strong recommendations can be made. Four weak recommendations based on the amount and consistency of evidence, including degree of efficacy and safety, are: 1) epidural injections for herpes zoster; 2) steroid injections for radiculopathy; 3) SCS for FBSS; and 4) SCS for CRPS type 1. Based on the available data, we recommend not to use sympathetic blocks for PHN nor radiofrequency lesions for radiculopathy. No other conclusive recommendations can be made due to the poor quality of available data. Whenever possible, these interventions should either be part of randomized clinical trials or documented in pain registries. Priorities for future research include randomized clinical trials, long-term studies, and head-to-head comparisons among different interventional and noninterventional treatments.

Indexed as

Complex Regional Pain SyndromesFailed Back Surgery SyndromeHumansNeuralgiaPain ManagementPeripheral Nervous System DiseasesRadiculopathyRandomized Controlled Trials as TopicTrigeminal NeuralgiaClinical trialsEvidence-based recommendationsIntrathecal medicationNeural blockadeNeuropathic painNeurosurgerySpinal cord stimulation

Identifiers

PMID23748119
PMCPMC4484720
OpenAlexW2132643178

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.