ReviewFrontiers in bioscience (Elite edition)2013
Biomarkers of bipolar disorder: specific or shared with schizophrenia?
Review in Frontiers in bioscience (Elite edition), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of sleep and circadian rhythms disturbances in individuals at high-risk of developing or with early onset of bipolar disorders.Neuroscience and biobehavioral reviews · 2022Pooled it
- Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.Molecular psychiatry · 2021Pooled it
- Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes.Schizophrenia bulletin · 2026Article
- Clinical Predictors of Cognitive Impairment in a Cohort of Patients with Older Age Bipolar Disorder.Brain sciences · 2025Article
- How pharmacology can aid in the diagnosis of mental disorders.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Developing a clinical decision tool based on electroretinogram to monitor the risk of severe mental illness.BMC psychiatry · 2022Article
- Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes.Communications biology · 2022Article
- Machine learning-based ability to classify psychosis and early stages of disease through parenting and attachment-related variables is associated with social cognition.BMC psychology · 2021Article
- Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative.International journal of bipolar disorders · 2019Review
- Can an Integrated Science Approach to Precision Medicine Research Improve Lithium Treatment in Bipolar Disorders?Frontiers in psychiatry · 2018Review
- Bipolar disorder risk geneJournal of psychiatry & neuroscience : JPN · 2017Article
- Transdiagnostic neural markers of emotion-cognition interaction in psychotic disorders.Journal of abnormal psychology · 2016Article
- Concepts and misconceptions regarding clinical staging models.Journal of psychiatry & neuroscience : JPN · 2016Article
- Neurodevelopmental Disorders or Early Death in Siblings of Children With Cerebral Palsy.Pediatrics · 2016Article
- Comparison of visual perceptual organization in schizophrenia and body dysmorphic disorder.Psychiatry research · 2015Article
- Quality of life in psychosis: prevalence and associated factors in a Nigerian clinical population.Community mental health journal · 2015Article
- Cerebellar volume in schizophrenia and bipolar I disorder with and without psychotic features.Acta psychiatrica Scandinavica · 2015Article
- Gene x environment interactions in schizophrenia and bipolar disorder: evidence from neuroimaging.Frontiers in psychiatry · 2013Review
- Neurocognitive Functioning in Schizophrenia and Bipolar Disorder: Clarifying Concepts of Diagnostic Dichotomy vs. Continuum.Frontiers in psychiatry · 2013Article
- Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kraepelin's observations of the differences in the course and outcome of dementia praecox and manic depression fundamentally influenced thinking about bipolar disorder (BP) and schizophrenia (SZ) for over a century. In modern times, there is increasing awareness that a greater understanding of the similarities between these two highly prevalent and disabling conditions can teach us as many lessons about the pathophysiology of severe mental disorders as does the pursuit of differentiating factors. We review publications on developmental, genetic, epidemiological, and outcome research that challenges the Kraepelian dichotomy. We highlight the increasing evidence of the overlap in genetic susceptibility. Neuro-developmental studies provide evidence of shared early pathological processes, whilst neurophysiological investigations also suggest that different genes may have a role in the development of both phenotypes. There is also evidence of overlapping neurocognitive phenotypes. It has become increasingly clear that a simple binary classification of these disorders represents an oversimplification. It may be more apposite to think in terms of genetic influences on six continuous symptom dimensions: neurobiological, cognitive, positive, negative, depressive and manic symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.