Evidence map›Paper›PMID 23747810›Full record

ArticleEuropean journal of medicinal chemistry2013

2-cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action.

Demetrio Raffa, Benedetta Maggio, Maria Valeria Raimondi, Maria Grazia Cusimano, Giandomenico Amico, Anna Carollo, Pier Giulio Conaldi, Ruoli Bai, Ernest Hamel, Giuseppe Daidone

Abstract read
In one paragraph

Article in European journal of medicinal chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Demetrio RaffaDipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche, Via Archirafi, 32, 90123 Palermo, Italy. demetrio.raffa@unipa.it
Benedetta Maggio
Maria Valeria Raimondi
Maria Grazia Cusimano
Giandomenico Amico
Anna Carollo
Pier Giulio Conaldi
Ruoli Bai
Ernest Hamel
Giuseppe Daidone

Funding

Intramural NIH HHS Z99 CA999999NCI NIH HHS Y99 CA999999
6 · The paper itself

Abstract

Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

Indexed as

Antineoplastic AgentsApoptosisBenzamidesCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansK562 CellsMCF-7 CellsMolecular StructureStructure-Activity RelationshipTumor Cells, CulturedAntineoplastic AgentsBenzamides2-(3-Phenylpropanamido)benzamides2-(3-Phenylpropiolamido)benzamides2-CinnamamidobenzamidesAntiproliferative activityApoptosisDYCGFIFOMKVDQP-UHFFFAOYSA-NGAEWJVNXMYWFOT-FPYGCLRLSA-NGLOIPBXNPXFMCD-CMDGGOBGSA-NGTMVKWANDDSBPP-UHFFFAOYSA-NGUWKFLZAMNTMFA-UHFFFAOYSA-NIBBGALVVPWZGNP-JXMROGBWSA-NIRYCZCAWVJZWKT-QPJJXVBHSA-NJZURWIGFELHAQF-UHFFFAOYSA-NLIWFXFAWCAUFBU-UHFFFAOYSA-NLRIOFNWWMBLPSV-RMKNXTFCSA-NMTEXNJMFEMIDJZ-CSKARUKUSA-NMVXMFTXNNUIRAF-UHFFFAOYSA-NMWHVYZNXRYFKFD-UHFFFAOYSA-NOEHLQIRCXNADOK-JXMROGBWSA-NPIQFLKOEQNXADK-QPJJXVBHSA-NQUNOMTLXTSUWOB-CMDGGOBGSA-NRHBJSXACCJTPRE-UHFFFAOYSA-NUSJUKEPNAZAKSG-UHFFFAOYSA-NWMHHXKMPUMTPIJ-RMKNXTFCSA-NWPPDXKZWCFUROB-UHFFFAOYSA-NXMXNTDIXMAUMEJ-UHFFFAOYSA-NZLNSPXKNAWBJIG-ZHACJKMWSA-NZXBUZBGNIFHLGX-UHFFFAOYSA-N

Identifiers

PMID23747810
PMCPMC3731050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.