ArticleBehavioural brain research2013
Effects of stimulus salience on touchscreen serial reversal learning in a mouse model of fragile X syndrome.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Assessing cognitive flexibility in mice using a custom-built touchscreen chamber.Frontiers in behavioral neuroscience · 2025Article
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- Fmr1-KO mice failure to detect object novelty associates with a post-test decrease of structural and synaptic plasticity upstream of the hippocampus.Scientific reports · 2023Article
- Enhanced fear limits behavioral flexibility in Shank2-deficient mice.Molecular autism · 2022Article
- Working memory and pattern separation in founder strains of the BXD recombinant inbred mouse panel.Scientific reports · 2022Article
- Parallel learning and cognitive flexibility impairments betweenFrontiers in behavioral neuroscience · 2022Article
- Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility.Nature communications · 2019Article
- The Virtual-Environment-Foraging Task enables rapid training and single-trial metrics of rule acquisition and reversal in head-fixed mice.Scientific reports · 2019Article
- Visual Discrimination, Serial Reversal, and Extinction Learning in theFrontiers in behavioral neuroscience · 2019Article
- Cerebellar contribution to higher and lower order rule learning and cognitive flexibility in mice.Neuroscience · 2017Article
- BALB/c Mice Can Learn Touchscreen Visual Discrimination and Reversal Tasks Faster than C57BL/6 Mice.Frontiers in behavioral neuroscience · 2017Article
- Putative Microcircuit-Level Substrates for Attention Are Disrupted in Mouse Models of Autism.Biological psychiatry · 2016Article
- Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice.ACS chemical neuroscience · 2015Article
- Performance of C57BL/6J and DBA/2J mice on a touchscreen-based attentional set-shifting task.Behavioural brain research · 2014Article
- Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models.Frontiers in cellular neuroscience · 2014Review
- Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model.Frontiers in behavioral neuroscience · 2013Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability in males and the most common genetic cause of autism. Although executive dysfunction is consistently found in humans with FXS, evidence of executive dysfunction in Fmr1 KO mice, a mouse model of FXS, has been inconsistent. One possible explanation for this is that executive dysfunction in Fmr1 KO mice, similar to humans with FXS, is only evident when cognitive demands are high. Using touchscreen operant conditioning chambers, male Fmr1 KO mice and their male wildtype littermates were tested on the acquisition of a pairwise visual discrimination followed by four serial reversals of the response rule. We assessed reversal learning performance under two different conditions. In the first, the correct stimulus was salient and the incorrect stimulus was non-salient. In the second and more challenging condition, the incorrect stimulus was salient and the correct stimulus was non-salient; this increased cognitive load by introducing conflict between sensory-driven (i.e., bottom-up) and task-dependent (i.e., top-down) signals. Fmr1 KOs displayed two distinct impairments relative to wildtype littermates. First, Fmr1 KOs committed significantly more learning-type errors during the second reversal stage, but only under high cognitive load. Second, during the first reversal stage, Fmr1 KOs committed significantly more attempts to collect a reward during the timeout following an incorrect response. These findings indicate that Fmr1 KO mice display executive dysfunction that, in some cases, is only evident under high cognitive load.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.