ArticleDevelopmental biology2013
The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Harnessing Intelligence from Brain Cells In Vitro.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Abamectin Causes Neurotoxicity in Zebrafish Embryos.International journal of molecular sciences · 2025Article
- Gsx2, but not Gsx1, is necessary for early forebrain patterning and long-term survival in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes.Frontiers in neuroscience · 2022Review
- LacZ-reporter mapping of Dlx5/6 expression and genoarchitectural analysis of the postnatal mouse prethalamus.The Journal of comparative neurology · 2021Article
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- Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus.Developmental biology · 2018Article
- Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis.Scientific reports · 2017Article
- GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms byThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- vglut2 and gad expression reveal distinct patterns of dual GABAergic versus glutamatergic cotransmitter phenotypes of dopaminergic and noradrenergic neurons in the zebrafish brain.The Journal of comparative neurology · 2014Article
- The dlx5a/dlx6a genes play essential roles in the early development of zebrafish median fin and pectoral structures.PloS one · 2014Article
- Activity-dependent expression of neuronal PAS domain-containing protein 4 (npas4a) in the developing zebrafish brain.Frontiers in neuroanatomy · 2014Article
- Patterning, specification, and differentiation in the developing hypothalamus.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
During development of the mouse forebrain interneurons, the Dlx genes play a key role in a gene regulatory network (GRN) that leads to the GABAergic phenotype. Here, we have examined the regulatory relationships between the ascl1a, dlx, and gad1b genes in the zebrafish forebrain. Expression of ascl1a overlaps with dlx1a in the telencephalon and diencephalon during early forebrain development. The loss of Ascl1a function results in a loss of dlx expression, and subsequent losses of dlx5a and gad1b expression in the diencephalic prethalamus and hypothalamus. Loss of Dlx1a and Dlx2a function, and, to a lesser extent, of Dlx5a and Dlx6a, impairs gad1b expression in the prethalamus and hypothalamus. We conclude that dlx1a/2a act downstream of ascl1a but upstream of dlx5a/dlx6a and gad1b to activate GABAergic specification. This pathway is conserved in the diencephalon, but has diverged between mammals and teleosts in the telencephalon.
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