Evidence map›Paper›PMID 23747249›Full record

ArticleCell metabolism2013

Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.

Laurent Vergnes, Jessica M Lee, Robert G Chin, Johan Auwerx, Karen Reue

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  8. Article
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  12. Exploring endocrine FGFs - structures, functions and biomedical applications.International journal of biochemistry and molecular biology · 2024
    Review
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  15. Article
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  19. Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia.Frontiers in cellular and infection microbiology · 2021
    Review
  20. Genetic comorbidity between major depression and cardio-metabolic traits, stratified by age at onset of major depression.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Laurent VergnesDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jessica M LeeDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Robert G ChinDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Johan AuwerxEcole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Karen ReueDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: reuek@ucla.edu.
University of California, Los Angeles · USÉcole Polytechnique Fédérale de Lausanne · CH

Funding

Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 1985 to 2019
$50.2M
PREDOCTORAL TRAINING PROGRAM IN GENETIC MECHANISMS AT UCT32GM007104 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOBER, JAMES W · 1985 to 2011
$3.6M
Characterization of Diet1, a hypercholesterolemia resistance geneR01HL102661 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2010 to 2013
$1.5M
ISOLATION OF A HYPERCHOLESTEROLEMIA RESISTANCE GENER01HL058627 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 1998 to 2002
$787k
NHLBI NIH HHS HL028481NHLBI NIH HHS HL102661NHLBI NIH HHS P01 HL028481NHLBI NIH HHS R01 HL058627NHLBI NIH HHS R01 HL102661NIGMS NIH HHS GM007104-34NIGMS NIH HHS T32 GM007104
6 · The paper itself

Abstract

We identified a mutation in the Diet1 gene in a mouse strain that is resistant to hyperlipidemia and atherosclerosis. Diet1 encodes a 236 kD protein consisting of tandem low-density lipoprotein receptor and MAM (meprin-A5-protein tyrosine phosphatase mu) domains and is expressed in the enterocytes of the small intestine. Diet1-deficient mice exhibited an elevated bile acid pool size and impaired feedback regulation of hepatic Cyp7a1, which encodes the rate-limiting enzyme in bile acid synthesis. In mouse intestine and in cultured human intestinal cells, Diet1 expression levels influenced the production of fibroblast growth factor 15/19 (FGF15/19), a hormone that signals from the intestine to liver to regulate Cyp7a1. Transgenic expression of Diet1, or adenoviral-mediated Fgf15 expression, restored normal Cyp7a1 regulation in Diet-1-deficient mice. Diet1 and FGF19 proteins exhibited overlapping subcellular localization in cultured intestinal cells. These results establish Diet1 as a control point in enterohepatic bile acid signaling and lipid homeostasis.

Indexed as

Lipid MetabolismAnimalsBile Acids and SaltsCarrier ProteinsCells, CulturedCholesterol 7-alpha-HydroxylaseEnterocytesEnterohepatic CirculationFibroblast Growth FactorsHumansIntestinal MucosaIntestine, SmallMiceMice, Inbred C57BLMice, TransgenicMolecular Sequence DataBile Acids and SaltsCarrier ProteinsCholesterol 7-alpha-HydroxylaseCyp7a1 protein, mouseDiet1 protein, mousefibroblast growth factor 15, mouseFibroblast Growth Factors

Identifiers

PMID23747249
PMCPMC3956443
OpenAlexW2137885556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.