Evidence map›Paper›PMID 23747238›Full record

ArticleCell metabolism2013

Does a single nucleotide polymorphism in the FGFR explain the connection between diabetes and cancer?

Emily J Gallagher, Derek LeRoith

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Compound 15c, a Novel Dual Inhibitor of EGFRFrontiers in pharmacology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Emily J GallagherDivision of Endocrinology, Diabetes & Bone Disease and the Diabetes, Obesity, Metabolism Institute, Icahn School of Medicine at Sinai, 1 Gustave L. Levy Place, Atran 4(th) floor-36, Box 1055, New York, NY 10029-6574, USA.
Derek LeRoithDivision of Endocrinology, Diabetes & Bone Disease and the Diabetes, Obesity, Metabolism Institute, Icahn School of Medicine at Sinai, 1 Gustave L. Levy Place, Atran 4(th) floor-36, Box 1055, New York, NY 10029-6574, USA. Electronic address: derek.leroith@mssm.edu.
Icahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A polymorphism in the fibroblast growth factor receptor 4 gene has been associated with cancer progression and treatment resistance and is now reported to increase insulin secretion, providing a possible genetic link between hyperinsulinemia and cancer (Ezzat et al., 2013).

Indexed as

Adaptor Proteins, Signal TransducingAnimalsHumansInsulinInsulin SecretionProteinsReceptor, Fibroblast Growth Factor, Type 4STAT3 Transcription FactorSTAT5 Transcription FactorAdaptor Proteins, Signal TransducingFgfr4 protein, mouseGrb14 protein, mouseInsulinProteinsReceptor, Fibroblast Growth Factor, Type 4Stat3 protein, mouseSTAT3 Transcription FactorSTAT5 Transcription Factor

Identifiers

PMID23747238
OpenAlexW2065734290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.