ReviewThe Annals of thoracic surgery2013
Cardiac autonomic nerve stimulation in the treatment of heart failure.
Review in The Annals of thoracic surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- The physiology, anatomy and stimulation of the vagus nerve in epilepsy.The Journal of physiology · 2025Review
- Enhancing myocardial function with cardiac contractility modulation: potential and challenges.ESC heart failure · 2024Review
- Data-driven discovery of sparse dynamical model of cardiovascular system for model predictive control.Computers in biology and medicine · 2023Article
- Human in vitro neurocardiac coculture (ivNCC) assay development for evaluating cardiac contractility modulation.Physiological reports · 2022Article
- Validation and Reliability of a Novel Vagus Nerve Neurodynamic Test and Its Effects on Heart Rate in Healthy Subjects: Little Differences Between Sexes.Frontiers in neuroscience · 2021Article
- Investigating the Effects of Brainstem Neuronal Adaptation on Cardiovascular Homeostasis.Frontiers in neuroscience · 2020Article
- Theory of energy harvesting from heartbeat including the effects of pleural cavity and respiration.Proceedings. Mathematical, physical, and engineering sciences · 2017Article
- A novel controller based on state-transition models for closed-loop vagus nerve stimulation: Application to heart rate regulation.PloS one · 2017Article
- Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II.Hypertension (Dallas, Tex. : 1979) · 2016Review
- Long noncoding NONRATT021972 siRNA normalized abnormal sympathetic activity mediated by the upregulation of P2X7 receptor in superior cervical ganglia after myocardial ischemia.Purinergic signalling · 2016Article
- Short‑term vagal nerve stimulation improves left ventricular function following chronic heart failure in rats.Molecular medicine reports · 2015Article
- Sympathetic nerve fibers in human cervical and thoracic vagus nerves.Heart rhythm · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Research on the therapeutic modulation of cardiac autonomic tone by electrical stimulation has yielded encouraging early clinical results. Vagus nerve stimulation has reduced the rates of morbidity and sudden death from heart failure, but therapeutic vagus nerve stimulation is limited by side effects of hypotension and bradycardia. Sympathetic nerve stimulation that has been implemented in the experiment may exacerbate the sympathetic-dominated autonomic imbalance. In contrast, concurrent stimulation of both sympathetic and parasympathetic cardiac nerves increases myocardial contractility without increasing heart rate. This review assesses the current state of electrical stimulation of the cardiac autonomic nervous system to treat heart failure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.