ArticleCell stem cell2013
KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.
Article in Cell stem cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis.Cell stem cell · 2023Article
- Human pluripotent stem cell fate trajectories toward lung and hepatocyte progenitors.iScience · 2023Article
- Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance.The Journal of experimental medicine · 2022Article
- The Cellular and Molecular Landscape of Synchronous Pediatric Sialoblastoma and Hepatoblastoma.Frontiers in oncology · 2022Article
- VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway.Developmental cell · 2021Article
- Angiodiversity and organotypic functions of sinusoidal endothelial cells.Angiogenesis · 2021Review
- Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.Hepatology communications · 2020Article
- Differential role of natural killer group 2D in recognition and cytotoxicity of hepatocyte-like cells derived from embryonic stem cells and induced pluripotent stem cells.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival.Journal of hepatology · 2019Review
- Primary Mechanism Study ofCardiology research and practice · 2019Article
- Molecular regulation of mammalian hepatic architecture.Current topics in developmental biology · 2019Review
- Modeling Cancer with Pluripotent Stem Cells.Trends in cancer · 2016Review
- Functional Blood Progenitor Markers in Developing Human Liver Progenitors.Stem cell reports · 2016Article
- The mesenchymal transcription factor SNAI-1 instructs human liver specification.Stem cell research · 2016Article
- Hhex Is Necessary for the Hepatic Differentiation of Mouse ES Cells and Acts via Vegf Signaling.PloS one · 2016Article
- Generation of Self-Renewing Hepatoblasts From Human Embryonic Stem Cells by Chemical Approaches.Stem cells translational medicine · 2015Article
- Orchestrating liver development.Development (Cambridge, England) · 2015Review
- Derivation of Endodermal Progenitors From Pluripotent Stem Cells.Journal of cellular physiology · 2015Review
- PDGFRα in liver pathophysiology: emerging roles in development, regeneration, fibrosis, and cancer.Gene expression · 2015Review
- New Methods in Tissue Engineering: Improved Models for Viral Infection.Annual review of virology · 2014Article
Corrections and comments
- Commented on by
- Erratum issuedSourrisseau, Marion [corrected to Sourisseau,]
Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
Understanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks a hESC-derived hepatic progenitor. hESC-derived endoderm cells do not express KDR but, when cultured in media supporting hepatic differentiation, generate KDR+ hepatic progenitors and KDR- hepatic cells. KDR+ progenitors require active KDR signaling both to instruct their own differentiation into hepatic cells and to non-cell-autonomously support the functional maturation of cocultured KDR- hepatic cells. Analysis of human fetal livers suggests that similar progenitors are present in human livers. Lineage tracing in mice provides in vivo evidence of a KDR+ hepatic progenitor for fetal hepatoblasts, adult hepatocytes, and adult cholangiocytes. Altogether, our findings reveal that KDR is a conserved marker for endoderm-derived hepatic progenitors and a functional receptor instructing early liver development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.