ArticleBiological psychiatry2013
Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 83 citations in OpenAlex.
- A Longitudinal Study of Head Circumference Trajectories in Autism and Autistic Traits.Journal of autism and developmental disorders · 2026Article
- Genetic Insights into Head-to-Body Ratios Via Deep Learning-Based Image Segmentation and Implications for Common Diseases.Nature communications · 2025Article
- Evaluation of familial phenotype deviation to measure the impact of de novo mutations in autism.Genome medicine · 2025Article
- Brief Report: Risk Variants Could Inform Early Neurodevelopmental Outcome in Children with Developmental Disabilities.Journal of autism and developmental disorders · 2024Article
- Clinical correlates of diagnostic certainty in children and youths with Autistic Disorder.Molecular autism · 2024Article
- Head circumference growth in children with Autism Spectrum Disorder: trend and clinical correlates in the first five years of life.Frontiers in psychiatry · 2024Article
- Comparing autism phenotypes in children born extremely preterm and born at term.Autism research : official journal of the International Society for Autism Research · 2023Article
- Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction.Molecular autism · 2020Review
- Review
- Evidence against the "normalization" prediction of the early brain overgrowth hypothesis of autism.Molecular autism · 2020Article
- Neuropsychiatric "Comorbidity" as Causal Influence in Autism.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Review
- Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder.Frontiers in psychiatry · 2019Review
- Cortical interneuron function in autism spectrum condition.Pediatric research · 2019Review
- Longitudinal Anthropometric Assessment of Rhesus Macaque (Comparative medicine · 2018Article
- Identification of Developmental and Behavioral Markers Associated With Genetic Abnormalities in Autism Spectrum Disorder.The American journal of psychiatry · 2017Article
- Human induced pluripotent stem cells for modelling neurodevelopmental disorders.Nature reviews. Neurology · 2017Review
- Peabody Picture Vocabulary Test: Proxy for Verbal IQ in Genetic Studies of Autism Spectrum Disorder.Journal of autism and developmental disorders · 2017Article
- Genetic control of postnatal human brain growth.Current opinion in neurology · 2017Review
- Combined genome-wide linkage and targeted association analysis of head circumference in autism spectrum disorder families.Journal of neurodevelopmental disorders · 2017Article
- No evidence of early head circumference enlargements in children later diagnosed with autism in Israel.Molecular autism · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 15 institutions in 2 countries.
Funding
Abstract
backgroundBrain development follows a different trajectory in children with autism spectrum disorders (ASD) than in typically developing children. A proxy for neurodevelopment could be head circumference (HC), but studies assessing HC and its clinical correlates in ASD have been inconsistent. This study investigates HC and clinical correlates in the Simons Simplex Collection cohort.
methodsWe used a mixed linear model to estimate effects of covariates and the deviation from the expected HC given parental HC (genetic deviation). After excluding individuals with incomplete data, 7225 individuals in 1891 families remained for analysis. We examined the relationship between HC/genetic deviation of HC and clinical parameters.
resultsGender, age, height, weight, genetic ancestry, and ASD status were significant predictors of HC (estimate of the ASD effect = .2 cm). HC was approximately normally distributed in probands and unaffected relatives, with only a few outliers. Genetic deviation of HC was also normally distributed, consistent with a random sampling of parental genes. Whereas larger HC than expected was associated with ASD symptom severity and regression, IQ decreased with the absolute value of the genetic deviation of HC.
conclusionsMeasured against expected values derived from covariates of ASD subjects, statistical outliers for HC were uncommon. HC is a strongly heritable trait, and population norms for HC would be far more accurate if covariates including genetic ancestry, height, and age were taken into account. The association of diminishing IQ with absolute deviation from predicted HC values suggests HC could reflect subtle underlying brain development and warrants further investigation.
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