Evidence map›Paper›PMID 23746834›Full record

ArticleCell2013

This message will self-destruct: NMD regulates axon guidance.

Nicolas Preitner, Jie Quan, John G Flanagan

Abstract readComment
In one paragraph

Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Nicolas PreitnerDepartment of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
Jie Quan
John G Flanagan

Funding

SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
CELL-CELL SIGNALING IN VISUAL DEVELOPMENTR01EY011559 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI FLANAGAN, JOHN G · 1996 to 2016
$6.9M
Signal transduction in axon guidanceR01NS069913 · NINDS · HARVARD MEDICAL SCHOOL · PI John G Flanagan · 2011 to 2026
$4.5M
Identification and Function of Receptors and LigandsR37HD029417 · NICHD · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI FLANAGAN, JOHN G · 2002 to 2011
$4.0M
NEI NIH HHS R01 EY011559NICHD NIH HHS P30 HD018655NICHD NIH HHS R37 HD029417NINDS NIH HHS R01 NS069913
6 · The paper itself

Abstract

The navigation of axons to their final destination can involve a sequence of steps that require different sets of guidance receptors. In this issue, Colak et al. show that regulated intra-axonal protein synthesis coupled to nonsense-mediated mRNA decay (NMD) controls a switch in Robo3.2 expression that is critical for navigation.

Indexed as

Nonsense Mediated mRNA DecayAnimalsAxonsEmbryo, MammalianGrowth ConesMembrane ProteinsNerve Tissue ProteinsReceptors, Cell SurfaceRoundabout ProteinsSpinal CordMembrane ProteinsNerve Tissue ProteinsReceptors, Cell SurfaceRobo3 protein, mouseRoundabout Proteins

Identifiers

PMID23746834
PMCPMC3703776

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.