ArticleNeuron2013
A prestin motor in chicken auditory hair cells: active force generation in a nonmammalian species.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 86 citations in OpenAlex.
- High-frequency vocalizations and hearing in hummingbirds: what we know and opportunities for the future.The Journal of experimental biology · 2026Review
- Structural Mechanism of Prestin-Membrane Mechanotransduction.bioRxiv : the preprint server for biology · 2025Article
- High-frequency electrical tuning and linear filter properties of Knollenorgan electroreceptors of mormyrid electric fish.The Journal of physiology · 2025Article
- Anatomical and molecular insights into avian inner ear sensory hair cell regeneration.Developmental biology · 2025Review
- The inner core enables transient touch detection in the Pacinian corpuscle.Science advances · 2025Article
- SLC26 Anion Transporters.Handbook of experimental pharmacology · 2024Review
- Elevator-like movements of prestin mediate outer hair cell electromotility.Nature communications · 2023Article
- The continued importance of comparative auditory research to modern scientific discovery.Hearing research · 2023Review
- Of mice and chickens: Revisiting the RC time constant problem.Hearing research · 2022Review
- AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration.Signal transduction and targeted therapy · 2022Article
- Atypical tuning and amplification mechanisms in gecko auditory hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Frontiers in cell and developmental biology · 2022Article
- Article
- Identification and characterization of amphibian SLC26A5 using RNA-Seq.BMC genomics · 2021Article
- SK Current, Expressed During the Development and Regeneration of Chick Hair Cells, Contributes to the Patterning of Spontaneous Action Potentials.Frontiers in cellular neuroscience · 2021Article
- Review
- Diverse Mechanisms of Sound Frequency Discrimination in the Vertebrate Cochlea.Trends in neurosciences · 2020Review
- An In Vitro Study on Prestin Analog Gene in the Bullfrog Hearing Organs.Neural plasticity · 2020Article
- Auditory performance in bald eagles and red-tailed hawks: a comparative study of hearing in diurnal raptors.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Outer Hair Cells and Electromotility.Cold Spring Harbor perspectives in medicine · 2019Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Active force generation by outer hair cells (OHCs) underlies amplification and frequency tuning in the mammalian cochlea but whether such a process exists in nonmammals is unclear. Here, we demonstrate that hair cells of the chicken auditory papilla possess an electromechanical force generator in addition to active hair bundle motion due to mechanotransducer channel gating. The properties of the force generator, its voltage dependence and susceptibility to salicylate, as well as an associated chloride-sensitive nonlinear capacitance, suggest involvement of the chicken homolog of prestin, the OHC motor protein. The presence of chicken prestin in the hair cell lateral membrane was confirmed by immunolabeling studies. The hair bundle and prestin motors together create sufficient force to produce fast lateral displacements of the tectorial membrane. Our results imply that the first use of prestin as a motor protein occurred early in amniote evolution and was not a mammalian invention as is usually supposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.