ArticleBiophysical journal2013
New organelles by gene duplication in a biophysical model of eukaryote endomembrane evolution.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Quantifying the evolutionary paths to endomembranes.Cell reports · 2025Article
- Evolutionary origins of the lysosome-related organelle sorting machinery reveal ancient homology in post-endosome trafficking pathways.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genome doubling enabled the expansion of yeast vesicle traffic pathways.Scientific reports · 2022Article
- Size regulation of multiple organelles competing for a limiting subunit pool.PLoS computational biology · 2022Article
- Graph-theoretic constraints on vesicle traffic networks.Journal of biosciences · 2022Article
- Evolution of late steps in exocytosis: conservation and specialization of the exocyst complex.Wellcome open research · 2019Article
- Trisomy 21 Represses Cilia Formation and Function.Developmental cell · 2018Article
- Article
- On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype.Trends in cell biology · 2016Review
- A multi-functional tubulovesicular network as the ancestral eukaryotic endomembrane system.Biology · 2015Review
- Ancient dynamin segments capture early stages of host-mitochondrial integration.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Missing pieces of an ancient puzzle: evolution of the eukaryotic membrane-trafficking system.Cold Spring Harbor perspectives in biology · 2014Review
- The cell biology of the endocytic system from an evolutionary perspective.Cold Spring Harbor perspectives in biology · 2014Review
- Wine glasses and hourglasses: Non-adaptive complexity of vesicle traffic in microbial eukaryotes.Molecular and biochemical parasitologyArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
Extant eukaryotic cells have a dynamic traffic network that consists of diverse membrane-bound organelles exchanging matter via vesicles. This endomembrane system arose and diversified during a period characterized by massive expansions of gene families involved in trafficking after the acquisition of a mitochondrial endosymbiont by a prokaryotic host cell >1.8 billion years ago. Here we investigate the mechanistic link between gene duplication and the emergence of new nonendosymbiotic organelles, using a minimal biophysical model of traffic. Our model incorporates membrane-bound compartments, coat proteins and adaptors that drive vesicles to bud and segregate cargo from source compartments, and SNARE proteins and associated factors that cause vesicles to fuse into specific destination compartments. In simulations, arbitrary numbers of compartments with heterogeneous initial compositions segregate into a few compositionally distinct subsets that we term organelles. The global structure of the traffic system (i.e., the number, composition, and connectivity of organelles) is determined completely by local molecular interactions. On evolutionary timescales, duplication of the budding and fusion machinery followed by loss of cross-interactions leads to the emergence of new organelles, with increased molecular specificity being necessary to maintain larger organellar repertoires. These results clarify potential modes of early eukaryotic evolution as well as more recent eukaryotic diversification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.