ArticleBiophysical journal2013
Cholesterol translocation in a phospholipid membrane.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Mechanical Stimulation of Red Blood Cells Aging: Focusing on the Microfluidics Application.Micromachines · 2025Review
- Probing the Origins of the Disorder-to-Order Transition of a Modified Cholesterol in Ternary Lipid Bilayers.Journal of the American Chemical Society · 2024Article
- Article
- Protein-free domains in native and ferroptosis-driven oxidized cell membranes: a molecular dynamics study of biophysical properties and doxorubicin uptake.Frontiers in molecular biosciences · 2024Article
- Pathways and Mechanisms of Cellular Cholesterol Efflux-Insight From Imaging.Frontiers in cell and developmental biology · 2022Review
- Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosis.Cell reports · 2021Article
- Role of cholesterol flip-flop in oxidized lipid bilayers.Biophysical journal · 2021Article
- ATP-dependent hydroxylation of an unactivated primary carbon with water.Nature communications · 2020Article
- Raman Spectroscopy Study of Curvature-Mediated Lipid Packing and Sorting in Single Lipid Vesicles.Biophysical journal · 2019Article
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
- The asymmetry of plasma membranes and their cholesterol content influence the uptake of cisplatin.Scientific reports · 2019Article
- Optimal Hydrophobicity and Reorientation of Amphiphilic Peptides Translocating through Membrane.Biophysical journal · 2018Article
- Mechanisms underlying interactions between PAMAM dendron-grafted surfaces with DPPC membranes.RSC advances · 2018Article
- Analysis of killing of growing cells and dormant and germinated spores of Bacillus species by black silicon nanopillars.Scientific reports · 2017Article
- Impact of Lipid Composition and Receptor Conformation on the Spatio-temporal Organization of μ-Opioid Receptors in a Multi-component Plasma Membrane Model.PLoS computational biology · 2016Article
- Surface Density-Induced Pleating of a Lipid Monolayer Drives Nascent High-Density Lipoprotein Assembly.Structure (London, England : 1993) · 2015Article
- Membrane Contact Sites: Complex Zones for Membrane Association and Lipid Exchange.Lipid insights · 2015Review
- Dynamics of lipids, cholesterol, and transmembrane α-helices from microsecond molecular dynamics simulations.The journal of physical chemistry. B · 2014Article
- Synaptic vesicle morphology: a case of protein sorting?Current opinion in cell biology · 2014Review
- Atomistic Monte Carlo simulation of lipid membranes.International journal of molecular sciences · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholesterol (CHOL) molecules play a key role in modulating the rigidity of cell membranes and controlling intracellular transport and signal transduction. Using an all-atom molecular dynamics approach, we study the process of CHOL interleaflet transport (flip-flop) in a dipalmitoylphosphatidycholine (DPPC)-CHOL bilayer over a time period of 15 μs. We investigate the effect of the flip-flop process on mechanical stress across the bilayer and the role of CHOL in inducing molecular order in bilayer leaflets. The simulations are carried out at physiologically relevant CHOL concentration (30%), temperature (323 K), and pressure (1 bar). CHOL flip-flop events are observed with a rate constant of 3 × 10⁴s⁻¹. Once a flip-flop event is triggered, a CHOL molecule takes an average of 73 nanoseconds to migrate from one bilayer leaflet to the other.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.