Evidence map›Paper›PMID 23746374›Full record

ReviewClinical science (London, England : 1979)2013

Sex and gender differences in control of blood pressure.

Rodrigo Maranon, Jane F Reckelhoff

Abstract readReview
In one paragraph

Review in Clinical science (London, England : 1979), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 3 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 3 syntheses or guidelines pooled it, 261 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Aging enhances autonomic support of blood pressure in women.Hypertension (Dallas, Tex. : 1979) · 2014
    Trial
  8. Article
  9. A FunctionalAntioxidants (Basel, Switzerland) · 2026
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Obesity and hypertension by sex.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Aging and sex differences in salt sensitivity of blood pressure.Clinical science (London, England : 1979) · 2025
    Review
  20. Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rodrigo MaranonWomen's Health Research Center and Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.
Jane F Reckelhoff
University of Mississippi Medical Center · US

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI HALL, JOHN E · 1993 to 2018
$39.4M
HUMORAL FACTORS IN GENDER DIFFERENCES IN BP CONTROLR01HL066072 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI RECKELHOFF, JANE F · 2001 to 2015
$3.9M
Gender and susceptibility to kidney damage in high BP.R01HL069194 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI RECKELHOFF, JANE F · 2001 to 2010
$2.5M
NHLBI NIH HHS P01 HL051971NHLBI NIH HHS P01 HL51971NHLBI NIH HHS R01 HL066072NHLBI NIH HHS R01 HL069194NHLBI NIH HHS R01 HL 66072NHLBI NIH HHS R01 HL69194
6 · The paper itself

Abstract

In recent years, the interest in studying the impact of sex steroids and gender on the regulation of blood pressure and cardiovascular disease has been growing. Women are protected from most cardiovascular events compared with men until after menopause, and postmenopausal women are at increased risk of cardiovascular complications compared with premenopausal women. The pathophysiological mechanisms have not been elucidated, but are not likely to be as simple as the presence or absence of oestrogens, since hormone replacement therapy in elderly women in the Women's Health Initiative or HERS (Heart and Estrogen/progestin Replacement Study) did not provide primary or secondary prevention against cardiovascular events. Men are also thought to be at risk of cardiovascular disease at earlier ages than women, and these mechanisms too are not likely to be as simple as the presence of testosterone, since androgen levels fall in men with cardiovascular and other chronic diseases. In fact, many investigators now believe that it is the reduction in androgen levels that frequently accompanies chronic disease and may exacerbate cardiovascular disease in men. In the present review, the roles of sex steroids and gender in mediating or protecting against hypertension and cardiovascular disease will be discussed.

Indexed as

Sex CharacteristicsAndrogensBlood PressureCardiovascular DiseasesEstrogensFemaleGonadal Steroid HormonesHumansHypertensionMaleSex ChromosomesAndrogensEstrogensGonadal Steroid Hormones

Identifiers

PMID23746374
PMCPMC4283814
OpenAlexW2129010834

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.