Observational studyRedox report : communications in free radical research2013
Serum malondialdehyde levels, myeloperoxidase and catalase activities in patients with nephrotic syndrome.
Observational study in Redox report : communications in free radical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Dynamic Changes in Oxidative Stress Biomarkers in a Child with Idiopathic Nephrotic Syndrome: A Longitudinal Case Study.International journal of molecular sciences · 2025Article
- Ovariectomy in Canine Surgical Medicine: A Comparative Analysis of Surgical Approaches and the Nociceptive, Inflammatory, and Oxidative Stress Responses.Animals : an open access journal from MDPI · 2025Article
- Effect of surgery on oxidative stress and endogenous tocopherol concentrations in juvenile female dogs.Acta veterinaria Scandinavica · 2024Article
- Surgical Site Infiltration with Comfort-in Device and Traditional Syringe in Dogs Undergoing Regional Mastectomy: Evaluation of Intra- and Postoperative Pain and Oxidative Stress.Animals : an open access journal from MDPI · 2024Article
- Tetrandrine may treat membranous glomerulopathy via P13K/Akt signaling pathway regulation: therapeutic mechanism validation using Heymann nephritis rat model.Bioengineered · 2021Article
- Evaluation of postoperative pain and toxicological aspects of the use of dipyrone and tramadol in cats.Journal of feline medicine and surgery · 2020Article
- NOX-mediated impairment of PDGF-induced DNA synthesis in peripheral blood lymphocytes of children with idiopathic nephrotic syndrome.Pediatric research · 2017Article
- Combined Catalase and ADH Inhibition Ameliorates Ethanol-Induced Myocardial Dysfunction Despite Causing Oxidative Stress in Conscious Female Rats.Alcoholism, clinical and experimental research · 2017Article
- Naloxone pretreatment prevents kidney injury after liver ischemia reperfusion injury.International urology and nephrology · 2016Article
- Relationship between serum DHEAS and oxidative stress levels of body mass index in healthy postmenopausal women.Redox report : communications in free radical research · 2016Article
- Emerging Role of Myeloperoxidase in the Prognosis of Nephrotic Syndrome Patients Before and After Steroid Therapy.Journal of clinical and diagnostic research : JCDR · 2015Article
- Levosimendan displays anti-inflammatory effects and decreases MPO bioavailability in patients with severe heart failure.Scientific reports · 2015Article
- Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSome studies have indicated the pathophysiological importance of reactive oxygen species (ROS) in patients with nephrotic syndrome. Myeloperoxidase (MPO) is a leukocyte-derived enzyme-generating ROS that has been proposed to exert a wide array of pro-atherogenic effects throughout all stages of the atherosclerotic process. The aim of this study was to investigate the serum malondialdehyde (MDA) levels, MPO and catalase activities in patients with adult nephrotic syndrome. PATIENTS AND
methods Twenty-four patients with nephrotic syndrome and 24 healthy controls were enrolled. Serum MPO activity, catalase activity, and MDA levels were assessed.
resultsSerum MPO activity and MDA levels were significantly higher in patients with nephrotic syndrome than controls (both, P<0.001), while catalase activity was significantly lower (P<0.001). Serum catalase activity was found to be significantly correlated with MPO activity (r=-0.417, P=0.003) and MDA levels (r=-0.532, P=0.007). The serum MDA levels were also found to be significantly correlated with MPO activity (r=0.419, P=0.003).
conclusionsWe concluded that serum MPO activity and oxidative stress were increased and that serum catalase activity was decreased in patients with adult nephrotic syndrome. In addition, these results indicate that increased MPO activity is associated with an oxidant-antioxidant imbalance that may contribute to atherosclerosis in patients with adult nephrotic syndrome.
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