ReviewClinical and experimental pharmacology & physiology2013
Endothelial caveolar subcellular domain regulation of endothelial nitric oxide synthase.
Review in Clinical and experimental pharmacology & physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Regulation of nitric oxide generation and consumption.International journal of biological sciences · 2025Review
- The Effects of Acidosis on eNOS in the Systemic Vasculature: A Focus on Early Postnatal Ontogenesis.International journal of molecular sciences · 2022Review
- Calcitonin Gene Related Peptide, Adrenomedullin, and Adrenomedullin 2 Function in Uterine Artery During Human Pregnancy.Endocrinology · 2022Article
- Chrysin attenuates high-fat-diet-induced myocardial oxidative stress via upregulating eNOS and Nrf2 target genes in rats.Molecular and cellular biochemistry · 2021Article
- Sustained Maternal Smoking Triggers Endothelial-Mediated Oxidative Stress in the Umbilical Cord Vessels, Resulting in Vascular Dysfunction.Antioxidants (Basel, Switzerland) · 2021Article
- Gastrodin prevents homocysteine-induced human umbilical vein endothelial cells injury via PI3K/Akt/eNOS and Nrf2/ARE pathway.Journal of cellular and molecular medicine · 2021Article
- Perfluorooctane sulfonic acid (PFOS) exposure during pregnancy increases blood pressure and impairs vascular relaxation mechanisms in the adult offspring.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Nitric oxide in cellular adaptation and disease.Redox biology · 2020Review
- Endothelial nitric oxide synthase activation is required for heparin receptor effects on vascular smooth muscle cells.American journal of physiology. Cell physiology · 2020Article
- The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia-Review.International journal of molecular sciences · 2019Review
- Structural analysis of estrogen receptors: interaction between estrogen receptors and cav-1 within the caveolae†.Biology of reproduction · 2019Article
- eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization.PloS one · 2019Article
- Dietary fats modify vascular fat composition, eNOS localization within lipid rafts and vascular function in obesity.Physiological reports · 2018Article
- Altered Endothelial Nitric Oxide Signaling as a Paradigm for Maternal Vascular Maladaptation in Preeclampsia.Current hypertension reports · 2017Review
- Domain-Specific Partitioning of Uterine Artery Endothelial Connexin43 and Caveolin-1.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Nutraceuticals and Bioactive Components from Fish for Dyslipidemia and Cardiovascular Risk Reduction.Marine drugs · 2016Review
- Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells.Biology of reproduction · 2016Article
- Omega-3 Polyunsaturated Fatty Acids: Structural and Functional Effects on the Vascular Wall.BioMed research international · 2015Review
- Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Local effects of pregnancy on connexin proteins that mediate Ca2+-associated uterine endothelial NO synthesis.Hypertension (Dallas, Tex. : 1979) · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Complex regulatory processes alter the activity of endothelial nitric oxide synthase (eNOS) leading to nitric oxide (NO) production by endothelial cells under various physiological states. These complex processes require specific subcellular eNOS partitioning between plasma membrane caveolar domains and non-caveolar compartments. Translocation of eNOS from the plasma membrane to intracellular compartments is important for eNOS activation and subsequent NO biosynthesis. We present data reviewing and interpreting information regarding: (i) the coupling of endothelial plasma membrane receptor systems in the caveolar structure relative to eNOS trafficking; (ii) how eNOS trafficking relates to specific protein-protein interactions for inactivation and activation of eNOS; and (iii) how these complex mechanisms confer specific subcellular location relative to eNOS multisite phosphorylation and signalling. Dysfunction in the regulation of eNOS activation may contribute to several disease states, in particular gestational endothelial abnormalities (pre-eclampsia, gestational diabetes etc.), that have life-long deleterious health consequences that predispose the offspring to develop hypertensive disease, Type 2 diabetes and adiposity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.