ArticleEvolutionary applications2013
First steps in experimental cancer evolution.
Article in Evolutionary applications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications.Experimental & molecular medicine · 2025Review
- Adaptation in Outbred Sexual Yeast is Repeatable, Polygenic and Favors Rare Haplotypes.Molecular biology and evolution · 2022Article
- Article
- A phenotypic switch in the dispersal strategy of breast cancer cells selected for metastatic colonization.Proceedings. Biological sciences · 2020Article
- Selection of a malignant subpopulation from a colorectal cancer cell line.Oncology letters · 2020Article
- Cancer cell lines show high heritability for motility but not generation time.Royal Society open science · 2020Article
- Article
- Role of network-mediated stochasticity in mammalian drug resistance.Nature communications · 2019Article
- DNA Damage Stress: Cui Prodest?International journal of molecular sciences · 2019Review
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment.Precision clinical medicine · 2018Review
- Resource competition promotes tumour expansion in experimentally evolved cancer.BMC evolutionary biology · 2017Article
- ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key Players.International journal of molecular sciences · 2016Review
- Learning about the Importance of Mutation Prevention from Curable Cancers and Benign Tumors.Journal of Cancer · 2016Review
- Protecting the normal in order to better kill the cancer.Cancer medicine · 2015Review
- Evolutionary perspective of cancer: myth, metaphors, and reality.Evolutionary applications · 2015Article
- Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications.Genome medicine · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Evolutionary processes play a central role in the development, progression and response to treatment of cancers. The current challenge facing researchers is to harness evolutionary theory to further our understanding of the clinical progression of cancers. Central to this endeavour will be the development of experimental systems and approaches by which theories of cancer evolution can be effectively tested. We argue here that the experimental evolution approach - whereby evolution is observed in real time and which has typically employed microorganisms - can be usefully applied to cancer. This approach allows us to disentangle the ecological causes of natural selection, identify the genetic basis of evolutionary changes and determine their repeatability. Cell cultures used in cancer research share many of the desirable traits that make microorganisms ideal for studying evolution. As such, experimental cancer evolution is feasible and likely to give great insight into the selective pressures driving the evolution of clinically destructive cancer traits. We highlight three areas of evolutionary theory with importance to cancer biology that are amenable to experimental evolution: drug resistance, social evolution and resource competition. Understanding the diversity, persistence and evolution of cancers is vital for treatment and drug development, and an experimental evolution approach could provide strategic directions and focus for future research.
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