ArticleFrontiers in neural circuits2013
Adaptive enhancement of learning protocol in hippocampal cultured networks grown on multielectrode arrays.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
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- The technology, opportunities, and challenges of Synthetic Biological Intelligence.Biotechnology advances · 2023Review
- Learning populations with hubs govern the initiation and propagation of spontaneous bursts in neuronal networks after learning.Frontiers in neuroscience · 2022Article
- Spatial Memory in a Spiking Neural Network with Robot Embodiment.Sensors (Basel, Switzerland) · 2021Article
- A Method for Recording the Bioelectrical Activity of Neural Axons upon Stimulation with Short Pulses of Infrared Laser Radiation.Sovremennye tekhnologii v meditsine · 2021Article
- Plasticity and Adaptation in Neuromorphic Biohybrid Systems.iScience · 2020Review
- Spatial Properties of STDP in a Self-Learning Spiking Neural Network Enable Controlling a Mobile Robot.Frontiers in neuroscience · 2020Article
- Optimized Real-Time Biomimetic Neural Network on FPGA for Bio-hybridization.Frontiers in neuroscience · 2019Article
- Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology.Frontiers in neuroscience · 2019Article
- Design of Cultured Neuron Networks in vitro with Predefined Connectivity Using Asymmetric Microfluidic Channels.Scientific reports · 2017Article
- Gap junctional signaling in pattern regulation: Physiological network connectivity instructs growth and form.Developmental neurobiology · 2017Review
- Controlled placement of multiple CNS cell populations to create complex neuronal cultures.PloS one · 2017Article
- Selectivity of stimulus induced responses in cultured hippocampal networks on microelectrode arrays.Cognitive neurodynamics · 2016Article
- On Having No Head: Cognition throughout Biological Systems.Frontiers in psychology · 2016Review
- In vitro studies of neuronal networks and synaptic plasticity in invertebrates and in mammals using multielectrode arrays.Neural plasticity · 2015Review
- Closed-loop neuroscience and neuroengineering.Frontiers in neural circuits · 2014Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Learning in neuronal networks can be investigated using dissociated cultures on multielectrode arrays supplied with appropriate closed-loop stimulation. It was shown in previous studies that weakly respondent neurons on the electrodes can be trained to increase their evoked spiking rate within a predefined time window after the stimulus. Such neurons can be associated with weak synaptic connections in nearby culture network. The stimulation leads to the increase in the connectivity and in the response. However, it was not possible to perform the learning protocol for the neurons on electrodes with relatively strong synaptic inputs and responding at higher rates. We proposed an adaptive closed-loop stimulation protocol capable to achieve learning even for the highly respondent electrodes. It means that the culture network can reorganize appropriately its synaptic connectivity to generate a desired response. We introduced an adaptive reinforcement condition accounting for the response variability in control stimulation. It significantly enhanced the learning protocol to a large number of responding electrodes independently on its base response level. We also found that learning effect preserved after 4-6 h after training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.